8XZH
 
 | | Cryo-EM structure of the MM07-bound human APLNR-Gi complex | | 分子名称: | Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Wang, W, Ji, S, Zhang, Y. | | 登録日 | 2024-01-21 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structure-based design of non-hypertrophic apelin receptor modulator.
Cell, 187, 2024
|
|
8XOH
 | | Cryo-EM structure of GPR30-Gq complex structure in the presence of E2 | | 分子名称: | G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, H, Xu, P, Xu, H.E. | | 登録日 | 2024-01-01 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural and functional evidence that GPR30 is not a direct estrogen receptor.
Cell Res., 34, 2024
|
|
8XOJ
 | | Cryo-EM structure of GPR30-Gq complex structure in the presence of G-1 | | 分子名称: | G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, H, Xu, P, Xu, H.E. | | 登録日 | 2024-01-01 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural and functional evidence that GPR30 is not a direct estrogen receptor.
Cell Res., 34, 2024
|
|
8XOI
 | | Cryo-EM structure of GPR30-Gq complex structure in the presence of fulvestrant | | 分子名称: | G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, H, Xu, P, Xu, H.E. | | 登録日 | 2024-01-01 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural and functional evidence that GPR30 is not a direct estrogen receptor.
Cell Res., 34, 2024
|
|
8XOG
 | | Cryo-EM structure of apo-GPR30-Gq complex structure | | 分子名称: | G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, H, Xu, P, Xu, H.E. | | 登録日 | 2024-01-01 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural and functional evidence that GPR30 is not a direct estrogen receptor.
Cell Res., 34, 2024
|
|
8XOF
 | | Cryo-EM structure of Lys05 bound GPR30-Gq complex structure | | 分子名称: | G protein subunit q, G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Liu, H, Xu, P, Xu, H.E. | | 登録日 | 2024-01-01 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural and functional evidence that GPR30 is not a direct estrogen receptor.
Cell Res., 34, 2024
|
|
8XJK
 | | Cloprosetnol bound Prostaglandin F2-alpha receptor-Gq Protein Complex | | 分子名称: | (~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E},3~{R})-4-(3-chloranylphenoxy)-3-oxidanyl-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | | 登録日 | 2023-12-21 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors.
Cell Rep, 43, 2024
|
|
8XJM
 | | Latanoprost acid bound Prostaglandin F2-alpha receptor-Gq Protein Complex | | 分子名称: | Antibody fragment scFv16, Engineered miniGq, Fusion tag,Prostaglandin F2-alpha receptor,LgBiT, ... | | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | | 登録日 | 2023-12-21 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors.
Cell Rep, 43, 2024
|
|
8XJO
 | | U46619 bound Thromboxane A2 receptor-Gq Protein Complex | | 分子名称: | (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | | 登録日 | 2023-12-21 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors.
Cell Rep, 43, 2024
|
|
8XJN
 | | Cloprosetnol bound Thromboxane A2 receptor-Gq Protein Complex | | 分子名称: | (~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E},3~{R})-4-(3-chloranylphenoxy)-3-oxidanyl-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | | 登録日 | 2023-12-21 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors.
Cell Rep, 43, 2024
|
|
8XJL
 | | PGF2-alpha bound Prostaglandin F2-alpha receptor-Gq Protein Complex | | 分子名称: | (Z)-7-[(1R,2R,3R,5S)-3,5-bis(oxidanyl)-2-[(E,3S)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | | 登録日 | 2023-12-21 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors.
Cell Rep, 43, 2024
|
|
8XGR
 | | ETB-eGt complex bound to endothelin-1 | | 分子名称: | Camelid antibody VHH fragment, Endothelin receptor type B, Endothelin-1, ... | | 著者 | Oshima, H.S, Sano, F.K, Akasaka, H, Iwama, A, Shihoya, W, Nureki, O. | | 登録日 | 2023-12-15 | | 公開日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Optimizing cryo-EM structural analysis of G i -coupling receptors via engineered G t and Nb35 application.
Biochem.Biophys.Res.Commun., 693, 2024
|
|
8XBH
 | | Human GPR34 -Gi complex bound to M1 | | 分子名称: | (2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[3-[2-[(3-phenoxyphenyl)methoxy]phenyl]propanoyloxy]propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Kawahara, R, Shihoya, W, Nureki, O. | | 登録日 | 2023-12-06 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | | 主引用文献 | Structural basis for lysophosphatidylserine recognition by GPR34.
Nat Commun, 15, 2024
|
|
8XBE
 | | Human GPR34 -Gi complex bound to S3E-LysoPS | | 分子名称: | (2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[(~{Z})-octadec-9-enoyl]oxy-propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Kawahara, R, Shihoya, W, Nureki, O. | | 登録日 | 2023-12-06 | | 公開日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis for lysophosphatidylserine recognition by GPR34.
Nat Commun, 15, 2024
|
|
8V6U
 | | 5HT2AR-miniGq heterotrimer in complex with a novel agonist obtained from large scale docking | | 分子名称: | 4-{(3R)-1-[(1R)-1-(pyrimidin-2-yl)ethyl]piperidin-3-yl}phenol, 5-hydroxytryptamine receptor 2A, G protein alpha-subunit q (Gi2-mini-Gq chimera), ... | | 著者 | Gumpper, R.H, Wang, L, Kapolka, N, Skiniotis, G, Roth, B.L. | | 登録日 | 2023-12-03 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | AlphaFold2 structures guide prospective ligand discovery.
Science, 384, 2024
|
|
8X8N
 | | Cryo-EM structure of the octreotide-bound Somatostatin receptor 5-Gi protein complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha, ... | | 著者 | Xu, H.E, You, C, Zhao, L, Li, J. | | 登録日 | 2023-11-27 | | 公開日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Cryo-EM structure of the octreotide-bound Somatostatin receptor 5-Gi protein complex
To Be Published
|
|
8X8L
 | | Cryo-EM structure of the cortistatin 17-bound Somatostatin receptor 5-Gi protein complex | | 分子名称: | Cortistatin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, H.E, You, C, Zhao, L, Li, J. | | 登録日 | 2023-11-27 | | 公開日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Cryo-EM structure of the cortistatin 17-bound Somatostatin receptor 5-Gi protein complex
To Be Published
|
|
8X7A
 | | Treprostinil bound Prostacyclin Receptor G protein complex | | 分子名称: | 2-[[(1~{R},2~{R},3~{a}~{S},9~{a}~{S})-2-oxidanyl-1-[(3~{S})-3-oxidanyloctyl]-2,3,3~{a},4,9,9~{a}-hexahydro-1~{H}-cyclopenta[g]naphthalen-5-yl]oxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Wang, J.J, Jin, S, Zhang, H, Xu, Y, Hu, W, Jiang, Y, Chen, C, Wang, D.W, Xu, H.E, Wu, C. | | 登録日 | 2023-11-23 | | 公開日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.56 Å) | | 主引用文献 | Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs.
Sci Adv, 10, 2024
|
|
8X79
 | | MRE-269 bound Prostacyclin Receptor G protein complex | | 分子名称: | 2-[4-[(5,6-diphenylpyrazin-2-yl)-propan-2-yl-amino]butoxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Wang, J.J, Jin, S, Zhang, H, Xu, Y, Hu, W, Jiang, Y, Chen, C, Wang, D.W, Xu, H.E, Wu, C. | | 登録日 | 2023-11-23 | | 公開日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | | 主引用文献 | Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs.
Sci Adv, 10, 2024
|
|
8X2K
 | | a lipid receptor complex structure | | 分子名称: | (Z)-N-(2-hydroxyethyl)octadec-9-enamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Geng, C, Yang, D, Jun, X. | | 登録日 | 2023-11-09 | | 公開日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | a lipid receptor complex structure
To Be Published
|
|
8X17
 | | Cryo-EM structure of adenosine receptor A3AR bound to CF102 | | 分子名称: | Adenosine receptor A3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Cai, H, Xu, Y, Xu, H.E. | | 登録日 | 2023-11-06 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Cryo-EM structures of adenosine receptor A 3 AR bound to selective agonists.
Nat Commun, 15, 2024
|
|
8X16
 | | Cryo-EM structure of adenosine receptor A3AR bound to CF101 | | 分子名称: | Adenosine receptor A3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Cai, H, Xu, Y, Xu, H.E. | | 登録日 | 2023-11-06 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | | 主引用文献 | Cryo-EM structures of adenosine receptor A 3 AR bound to selective agonists.
Nat Commun, 15, 2024
|
|
8UWL
 | | 5-HT2AR bound to Lisuride in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM) | | 分子名称: | 5-hydroxytryptamine receptor 2A, G protein subunit q (Gi2-mini-Gq chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Barros-Alvarez, X, Kim, K, Panova, O, Roth, B.L, Skiniotis, G. | | 登録日 | 2023-11-06 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | AlphaFold2 structures guide prospective ligand discovery.
Science, 384, 2024
|
|
8WZ2
 | | Structure of 26RFa-pyroglutamylated RFamide peptide receptor complex | | 分子名称: | G-alpha q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Jin, S, Li, X, Xu, Y, Guo, S, Wu, C, Zhang, H, Yuan, Q, Xu, H.E, Xie, X, Jiang, Y. | | 登録日 | 2023-11-01 | | 公開日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | | 主引用文献 | Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor.
Cell Discov, 10, 2024
|
|
8UQO
 | | PLCb3-Gbg-Gaq complex on membranes | | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Falzone, M.E, MacKinnon, R. | | 登録日 | 2023-10-24 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | | 主引用文献 | The mechanism of G alpha q regulation of PLC beta 3 -catalyzed PIP2 hydrolysis.
Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
