4TWT
 
 | | Human TNFa dimer in complex with the semi-synthetic bicyclic peptide M21 | | 分子名称: | (2,4,6-trimethylbenzene-1,3,5-triyl)trimethanol, ALA-CYS-PRO-PRO-CYS-LEU-TRP-GLN-VAL-LEU-CYS-GLY, GLYCEROL, ... | | 著者 | Luzi, S, Kondo, Y, Bernard, E, Stadler, L, Winter, G, Holliger, P. | | 登録日 | 2014-07-01 | | 公開日 | 2015-02-04 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Subunit disassembly and inhibition of TNF alpha by a semi-synthetic bicyclic peptide.
Protein Eng.Des.Sel., 28, 2015
|
|
1OSG
 | | Complex between BAFF and a BR3 derived peptide presented in a beta-hairpin scaffold | | 分子名称: | BR3 derived PEPTIDE, MAGNESIUM ION, Tumor necrosis factor ligand superfamily member 13B | | 著者 | Gordon, N.C, Pan, B, Hymowitz, S.G, Yin, J.P, Kelley, R.F, Cochran, A.G, Yan, M, Dixit, V.M, Fairbrother, W.J, Starovasnik, M.A. | | 登録日 | 2003-03-19 | | 公開日 | 2003-05-27 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site
Biochemistry, 42, 2003
|
|
6MKB
 | | Crystal structure of murine 4-1BB ligand | | 分子名称: | SODIUM ION, SULFATE ION, Tumor necrosis factor ligand superfamily member 9, ... | | 著者 | Bitra, A, Zajonc, D.M, Doukov, T. | | 登録日 | 2018-09-25 | | 公開日 | 2018-12-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of the m4-1BB/4-1BBL complex reveals an unusual dimeric ligand that undergoes structural changes upon 4-1BB receptor binding.
J. Biol. Chem., 294, 2019
|
|
3WD5
 | | Crystal structure of TNFalpha in complex with Adalimumab Fab fragment | | 分子名称: | Adalimumab Heavy Chain, Adalimumab Light Chain, Tumor necrosis factor | | 著者 | Hu, S, Liang, S.Y, Guo, Y.J, Lou, Z.Y. | | 登録日 | 2013-06-06 | | 公開日 | 2013-08-14 | | 最終更新日 | 2015-07-01 | | 実験手法 | X-RAY DIFFRACTION (3.101 Å) | | 主引用文献 | Comparison of the inhibition mechanisms of adalimumab and infliximab in treating tumor necrosis factor alpha-associated diseases from a molecular view
J.Biol.Chem., 288, 2013
|
|
6MGE
 | | Structure of human 4-1BBL | | 分子名称: | GLYCEROL, PHOSPHATE ION, Tumor necrosis factor ligand superfamily member 9 | | 著者 | Kimberlin, C.R, Chin, S.M, Roe-Zurz, Z, Xu, A, Yang, Y. | | 登録日 | 2018-09-13 | | 公開日 | 2018-11-21 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab.
Nat Commun, 9, 2018
|
|
5Y9J
 | | BAFF in complex with belimumab | | 分子名称: | Tumor necrosis factor ligand superfamily member 13B, belibumab light chain, belimumab heavy chain | | 著者 | Heo, Y.-S, Shin, W. | | 登録日 | 2017-08-25 | | 公開日 | 2018-02-21 | | 最終更新日 | 2019-09-04 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus.
Nat Commun, 9, 2018
|
|
7KHX
 | | Mouse GITR-GITRL complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, ... | | 著者 | Wang, F, Chau, B, West, S.M, Strop, P. | | 登録日 | 2020-10-22 | | 公開日 | 2021-03-03 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.20569849 Å) | | 主引用文献 | Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions.
Nat Commun, 12, 2021
|
|
6D3N
 | | Crystal structure of h4-1BB ligand | | 分子名称: | GLYCEROL, Tumor necrosis factor ligand superfamily member 9 | | 著者 | Aruna, B, Zajonc, D.M, Doukov, T. | | 登録日 | 2018-04-16 | | 公開日 | 2018-05-09 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier.
J. Biol. Chem., 293, 2018
|
|
5YOY
 | | Crystal structure of the human tumor necrosis factor in complex with golimumab Fv | | 分子名称: | Golimumab heavy chain variable region, Golimumab light chain variable region, Tumor necrosis factor | | 著者 | Ono, M, Horita, S, Sato, Y, Nomura, Y, Iwata, S, Nomura, N. | | 登録日 | 2017-10-31 | | 公開日 | 2018-05-09 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.727 Å) | | 主引用文献 | Structural basis for tumor necrosis factor blockade with the therapeutic antibody golimumab
Protein Sci., 27, 2018
|
|
6OOY
 | | Asymmetric hTNF-alpha | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, Tumor necrosis factor, {1-[(2,5-dimethylphenyl)methyl]-1H-benzimidazol-2-yl}methanol | | 著者 | Arakaki, T.L, Edwards, T.E, Ceska, T. | | 登録日 | 2019-04-23 | | 公開日 | 2019-12-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.
Nat Commun, 10, 2019
|
|
6OP0
 | | Asymmetric hTNF-alpha | | 分子名称: | (R)-{1-[(2,5-dimethylphenyl)methyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-2-yl}(pyridin-4-yl)methanol, Tumor necrosis factor | | 著者 | Arakaki, T.L, Edwards, T.E, Fairman, J.W, Davies, D.R, Foley, A, Ceska, T. | | 登録日 | 2019-04-23 | | 公開日 | 2019-12-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.
Nat Commun, 10, 2019
|
|
2ZPX
 | |
6OOZ
 | | Asymmetric hTNF-alpha | | 分子名称: | (S)-{1-[(2,5-dimethylphenyl)methyl]-1H-benzimidazol-2-yl}(pyridin-4-yl)methanol, CHLORIDE ION, Tumor necrosis factor | | 著者 | Arakaki, T.L, Edwards, T.E, Fox III, D, Lecomte, F, Ceska, T. | | 登録日 | 2019-04-23 | | 公開日 | 2019-12-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.
Nat Commun, 10, 2019
|
|
4MXV
 | | Structure of Lymphotoxin alpha bound to anti-LTa Fab | | 分子名称: | Lymphotoxin-alpha, anti-Lymphotoxin alpha antibody heavy chain, anti-Lymphotoxin alpha antibody light chain | | 著者 | Yin, J.P, Hymowitz, S.G. | | 登録日 | 2013-09-26 | | 公開日 | 2013-11-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Dimerization of LT beta R by LT alpha 1 beta 2 is necessary and sufficient for signal transduction.
Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
2ZJC
 | | TNFR1 selectve TNF mutant; R1-6 | | 分子名称: | GLYCEROL, Tumor necrosis factor | | 著者 | Mukai, Y, Yamagata, Y, Tsutsumi, Y. | | 登録日 | 2008-03-05 | | 公開日 | 2009-01-20 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure-Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant
J.Mol.Biol., 385, 2009
|
|
4KG8
 | | Crystal structure of light mutant | | 分子名称: | Tumor necrosis factor ligand superfamily member 14 | | 著者 | Liu, W, Zhan, C, Kumar, P.R, Bonanno, J.B, Nathenson, S.G, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) | | 登録日 | 2013-04-28 | | 公開日 | 2013-08-07 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.
Structure, 22, 2014
|
|
3B9I
 | |
4EN0
 | | Crystal structure of light | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, PHOSPHATE ION, ... | | 著者 | Zhan, C, Liu, W, Patskovsky, Y, Ramagopal, U.A, Bonanno, J.B, Nathenson, S.G, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) | | 登録日 | 2012-04-12 | | 公開日 | 2012-05-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.
Structure, 22, 2014
|
|
5L19
 | |
5M2J
 | | Complex between human TNF alpha and Llama VHH2 | | 分子名称: | Anti-(ED-B) scFV, Tumor necrosis factor | | 著者 | Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H. | | 登録日 | 2016-10-13 | | 公開日 | 2017-08-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.
Front Immunol, 8, 2017
|
|
5M2M
 | | Complex between human TNF alpha and Llama VHH3 | | 分子名称: | Llama nanobody VHH3, Tumor necrosis factor | | 著者 | Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H. | | 登録日 | 2016-10-13 | | 公開日 | 2017-08-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.
Front Immunol, 8, 2017
|
|
7JRA
 | |
5M2I
 | | Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1 | | 分子名称: | Tumor necrosis factor, VHH1 | | 著者 | Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H. | | 登録日 | 2016-10-13 | | 公開日 | 2017-08-30 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.
Front Immunol, 8, 2017
|
|
1D2Q
 | | CRYSTAL STRUCTURE OF HUMAN TRAIL | | 分子名称: | TNF-RELATED APOPTOSIS INDUCING LIGAND | | 著者 | Cha, S.-S. | | 登録日 | 1999-09-27 | | 公開日 | 2000-02-11 | | 最終更新日 | 2018-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | 2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity.
Immunity, 11, 1999
|
|
1DG6
 | | CRYSTAL STRUCTURE OF APO2L/TRAIL | | 分子名称: | APO2L/TNF-RELATED APOPOTIS INDUCING LIGAND (TRAIL), CHLORIDE ION, ZINC ION | | 著者 | Hymowitz, S.G, O'ConnelL, M.P, Ultsch, M.H, de Vos, A.M, Kelley, R.F. | | 登録日 | 1999-11-23 | | 公開日 | 2000-01-26 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL.
Biochemistry, 39, 2000
|
|
