6OOZ

Asymmetric hTNF-alpha

Summary for 6OOZ

Entry DOI	10.2210/pdb6ooz/pdb
Descriptor	Tumor necrosis factor, CHLORIDE ION, (S)-{1-[(2,5-dimethylphenyl)methyl]-1H-benzimidazol-2-yl}(pyridin-4-yl)methanol, ... (4 entities in total)
Functional Keywords	tumour necrosis factor alpha, tnf, asymmetric, protein-protein interaction inhibitor, rheumatoid arthritis, cytokine
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	52490.85
Authors	Arakaki, T.L.,Edwards, T.E.,Fox III, D.,Lecomte, F.,Ceska, T. (deposition date: 2019-04-23, release date: 2019-12-25, Last modification date: 2024-04-03)
Primary citation	O'Connell, J.,Porter, J.,Kroeplien, B.,Norman, T.,Rapecki, S.,Davis, R.,McMillan, D.,Arakaki, T.,Burgin, A.,Fox Iii, D.,Ceska, T.,Lecomte, F.,Maloney, A.,Vugler, A.,Carrington, B.,Cossins, B.P.,Bourne, T.,Lawson, A. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun, 10:5795-5795, 2019 Cited by PubMed: 31857588 DOI: 10.1038/s41467-019-13616-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation