8A0Z
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7ZZX
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8A0N
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8G4Z
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![BU of 8g4z by Molmil](/molmil-images/mine/8g4z) | E. coli DHFR complex with NADP+ and folate: EF-X off model by Laue diffraction (no electric field) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Klureza, M.A, Hekstra, D.R. | 登録日 | 2023-02-10 | 公開日 | 2024-01-03 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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8G50
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![BU of 8g50 by Molmil](/molmil-images/mine/8g50) | E. coli DHFR complex with NADP+ and folate: EF-X excited state model by Laue diffraction (electric field along b axis; 8-fold extrapolation of structure factor differences) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Klureza, M.A, Hekstra, D.R. | 登録日 | 2023-02-10 | 公開日 | 2024-01-03 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism. Proc.Natl.Acad.Sci.USA, 121, 2024
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6XG4
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![BU of 6xg4 by Molmil](/molmil-images/mine/6xg4) | X-ray structure of Escherichia coli dihydrofolate reductase L28R mutant in complex with trimethoprim | 分子名称: | CHLORIDE ION, Dihydrofolate reductase, GLYCEROL, ... | 著者 | Gaszek, I.K, Manna, M.S, Borek, D, Toprak, E. | 登録日 | 2020-06-16 | 公開日 | 2021-03-24 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A trimethoprim derivative impedes antibiotic resistance evolution. Nat Commun, 12, 2021
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6XG5
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![BU of 6xg5 by Molmil](/molmil-images/mine/6xg5) | X-ray structure of Escherichia coli dihydrofolate reductase in complex with trimethoprim | 分子名称: | CHLORIDE ION, Dihydrofolate reductase, GLYCEROL, ... | 著者 | Gaszek, I.K, Manna, M.S, Borek, D, Toprak, E. | 登録日 | 2020-06-16 | 公開日 | 2021-03-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A trimethoprim derivative impedes antibiotic resistance evolution. Nat Commun, 12, 2021
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6VS8
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6VSF
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![BU of 6vsf by Molmil](/molmil-images/mine/6vsf) | Mycobacterium tuberculosis dihydrofolate reductase in complex with 4-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-4-oxobutanoic acid(fragment 16) | 分子名称: | 4-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-4-oxobutanoic acid, COBALT (II) ION, Dihydrofolate reductase, ... | 著者 | Ribeiro, J.A, Dias, M.V.B. | 登録日 | 2020-02-11 | 公開日 | 2020-07-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.012 Å) | 主引用文献 | Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase fromMycobacterium tuberculosis. Acs Infect Dis., 6, 2020
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6VS6
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6VV6
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![BU of 6vv6 by Molmil](/molmil-images/mine/6vv6) | Mycobacterium tuberculosis dihydrofolate reductase in complex with JEB113 | 分子名称: | 1-(4-fluorophenyl)-5-[3-(1H-indol-3-yl)propoxy]-1H-pyrazole-4-carboxylic acid, COBALT (II) ION, Dihydrofolate reductase, ... | 著者 | Ribeiro, J.A, Dias, M.V.B, Chaves-Pacheco, S.M. | 登録日 | 2020-02-17 | 公開日 | 2020-07-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.235 Å) | 主引用文献 | Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase fromMycobacterium tuberculosis. Acs Infect Dis., 6, 2020
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3EEK
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3EEM
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![BU of 3eem by Molmil](/molmil-images/mine/3eem) | Candida glabrata Dihydrofolate Reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-(2,6-dimethylphenyl)phenyl)prop-1-ynyl]-6-methylpyrimidine(UCP111D26M) and NADPH | 分子名称: | 5-[(3R)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Liu, J, Anderson, A. | 登録日 | 2008-09-04 | 公開日 | 2009-08-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors Chem.Biol.Drug Des., 73, 2009
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3EEJ
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3EEL
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![BU of 3eel by Molmil](/molmil-images/mine/3eel) | Candida glabrata Dihydrofolate Reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-(3,5-dimethylphenyl)phenyl)prop-1-ynyl]-6-methylpyrimidine(UCP11153TM) and NADPH | 分子名称: | 5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Liu, J, Anderson, A. | 登録日 | 2008-09-04 | 公開日 | 2009-08-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors Chem.Biol.Drug Des., 73, 2009
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4CD2
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![BU of 4cd2 by Molmil](/molmil-images/mine/4cd2) | LIGAND INDUCED CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEXES WITH FOLATE AND NADP+ | 分子名称: | DIHYDROFOLATE REDUCTASE, FOLIC ACID | 著者 | Cody, V, Galitsky, N, Rak, D, Luft, J.R, Pangborn, W, Queener, S.F. | 登録日 | 1999-03-18 | 公開日 | 2000-03-29 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+. Biochemistry, 38, 1999
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8UCX
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8SSX
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![BU of 8ssx by Molmil](/molmil-images/mine/8ssx) | Crystal structure of Bacillus anthracis dihydrofolate reductase at 1.65-A resolution | 分子名称: | 1,2-ETHANEDIOL, Dihydrofolate reductase, SULFATE ION | 著者 | Shaw, G.X, Li, Y, Wu, Y, Yan, H, Ji, X. | 登録日 | 2023-05-09 | 公開日 | 2023-05-17 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal structure of Bacillus anthracis dihydrofolate reductase at 1.65-A resolution To be published
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8SZE
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![BU of 8sze by Molmil](/molmil-images/mine/8sze) | Crystal structure of Yersinia pestis dihydrofolate reductase in complex with Trimethoprim | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Dihydrofolate reductase, ... | 著者 | Shaw, G.X, Cherry, S, Tropea, J.E, Waugh, D.S, Ji, X. | 登録日 | 2023-05-29 | 公開日 | 2023-06-07 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of Yersinia pestis dihydrofolate reductase in complex with Trimethoprim To be published
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8SZD
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![BU of 8szd by Molmil](/molmil-images/mine/8szd) | Crystal structure of Yersinia pestis dihydrofolate reductase at 1.25-A resolution | 分子名称: | CHLORIDE ION, Dihydrofolate reductase, MAGNESIUM ION, ... | 著者 | Shaw, G.X, Cherry, S, Tropea, J.E, Waugh, D.S, Ji, X. | 登録日 | 2023-05-29 | 公開日 | 2023-06-07 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Crystal structure of Yersinia pestis dihydrofolate reductase at 1.25-A resolution To be published
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4DFR
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![BU of 4dfr by Molmil](/molmil-images/mine/4dfr) | CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE | 分子名称: | CALCIUM ION, CHLORIDE ION, DIHYDROFOLATE REDUCTASE, ... | 著者 | Filman, D.J, Matthews, D.A, Bolin, J.T, Kraut, J. | 登録日 | 1982-06-25 | 公開日 | 1982-10-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate. J.Biol.Chem., 257, 1982
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4DDR
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![BU of 4ddr by Molmil](/molmil-images/mine/4ddr) | Human dihydrofolate reductase complexed with NADPH and P218 | 分子名称: | 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Yuthavong, Y, Tarnchompoo, B, Vilaivan, T, Chitnumsub, P, Kamchonwongpaisan, S, Charman, S.A, McLennan, D.N, White, K.L, Vivas, L, Bongard, E, Thongphanchang, C, Taweechai, S, Vanichtanankul, J, Rattanajak, R, Arwon, U, Fantauzzi, P, Yuvaniyama, J, Charman, W.N, Matthews, D. | 登録日 | 2012-01-19 | 公開日 | 2012-11-14 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target Proc.Natl.Acad.Sci.USA, 109, 2012
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2L28
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![BU of 2l28 by Molmil](/molmil-images/mine/2l28) | Solution structure of lactobacillus casei dihydrofolate reductase apo-form, 25 conformers | 分子名称: | Dihydrofolate reductase | 著者 | Polshakov, V.I, Birdsall, B, Feeney, J. | 登録日 | 2010-08-13 | 公開日 | 2011-04-06 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR Structures of Apo L. casei Dihydrofolate Reductase and Its Complexes with Trimethoprim and NADPH: Contributions to Positive Cooperative Binding from Ligand-Induced Refolding, Conformational Changes, and Interligand Hydrophobic Interactions. Biochemistry, 50, 2011
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2LF1
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![BU of 2lf1 by Molmil](/molmil-images/mine/2lf1) | Solution structure of L. casei dihydrofolate reductase complexed with NADPH, 30 structures | 分子名称: | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Polshakov, V, Feeney, J, Birdsall, B, Kovalevskaya, N. | 登録日 | 2011-06-28 | 公開日 | 2011-12-21 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structures of apo L. casei dihydrofolate reductase and its complexes with trimethoprim and NADPH: contributions to positive cooperative binding from ligand-induced refolding, conformational changes, and interligand hydrophobic interactions Biochemistry, 50, 2011
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2ITH
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