8G50
| E. coli DHFR complex with NADP+ and folate: EF-X excited state model by Laue diffraction (electric field along b axis; 8-fold extrapolation of structure factor differences) | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Brookner, D.E, Klureza, M.A, Hekstra, D.R. | 登録日 | 2023-02-10 | 公開日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | E. coli DHFR complex with NADP+ and folate: EF-X excited state model by Laue diffraction (electric field along b axis; 8-fold extrapolation of structure factor differences) To Be Published
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3DRC
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6XG4
| X-ray structure of Escherichia coli dihydrofolate reductase L28R mutant in complex with trimethoprim | 分子名称: | CHLORIDE ION, Dihydrofolate reductase, GLYCEROL, ... | 著者 | Gaszek, I.K, Manna, M.S, Borek, D, Toprak, E. | 登録日 | 2020-06-16 | 公開日 | 2021-03-24 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A trimethoprim derivative impedes antibiotic resistance evolution. Nat Commun, 12, 2021
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6XG5
| X-ray structure of Escherichia coli dihydrofolate reductase in complex with trimethoprim | 分子名称: | CHLORIDE ION, Dihydrofolate reductase, GLYCEROL, ... | 著者 | Gaszek, I.K, Manna, M.S, Borek, D, Toprak, E. | 登録日 | 2020-06-16 | 公開日 | 2021-03-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A trimethoprim derivative impedes antibiotic resistance evolution. Nat Commun, 12, 2021
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5UIO
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8A0Z
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7ZZX
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8A0N
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5W3Q
| L28F E.coli DHFR in complex with NADPH | 分子名称: | CALCIUM ION, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Oyen, D, Wright, P.E, Wilson, I.A. | 登録日 | 2017-06-08 | 公開日 | 2017-08-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.401 Å) | 主引用文献 | Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion. J. Am. Chem. Soc., 139, 2017
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4QJZ
| Pneumocystis carinii dihydrofolate reductase ternary complex with NADPH and the inhibitor 24, (N~6~-METHYL-N~6~-(NAPHTHALEN-1-YL)PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE) | 分子名称: | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N~6~-methyl-N~6~-(naphthalen-1-yl)pyrido[2,3-d]pyrimidine-2,4,6-triamine | 著者 | Cody, V. | 登録日 | 2014-06-05 | 公開日 | 2015-06-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase. Acta Crystallogr F Struct Biol Commun, 71, 2015
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4QHV
| Crystal structure of human dihydrofolate reductase as complex with pyridopyrimidine 22 (N~6~-METHYL-N~6~-[4-(PROPAN-2-YL)PHENYL]PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE) | 分子名称: | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N~6~-methyl-N~6~-[4-(propan-2-yl)phenyl]pyrido[2,3-d]pyrimidine-2,4,6-triamine, ... | 著者 | Cody, V. | 登録日 | 2014-05-29 | 公開日 | 2015-06-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase. Acta Crystallogr F Struct Biol Commun, 71, 2015
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4QI9
| Crystal structure of dihydrofolate reductase from Yersinia pestis complexed with methotrexate | 分子名称: | Dihydrofolate reductase, METHOTREXATE | 著者 | Maltseva, N, Kim, Y, Makowska-Grzyska, M, Mulligan, R, Shatsman, S, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2014-05-30 | 公開日 | 2014-07-02 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.297 Å) | 主引用文献 | Crystal structure of dihydrofolate reductase from Yersinia pestis complexed with methotrexate To be Published
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4QJC
| Human dihydrofolate reductase ternary complex with NADPH and inhibitor 26 (N~6~-METHYL-N~6~-(3,4,5-TRIFLUOROPHENYL)PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE) | 分子名称: | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N~6~-methyl-N~6~-(3,4,5-trifluorophenyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine | 著者 | Cody, V. | 登録日 | 2014-06-03 | 公開日 | 2015-06-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase. Acta Crystallogr F Struct Biol Commun, 71, 2015
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8CRH
| Crystal structure of Candida auris dihydrofolate reductase complexed with NADPH and cycloguanil | 分子名称: | 5-(4-chlorophenyl)-6,6-dimethyl-1,4-dihydro-1,3,5-triazine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Kirkman, T.J, Dias, M.V.B. | 登録日 | 2023-03-08 | 公開日 | 2023-08-02 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Crystal structure of dihydrofolate reductase from the emerging pathogenic fungus Candida auris. Acta Crystallogr D Struct Biol, 79, 2023
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5UIP
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5UIH
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7L9T
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2KGK
| Solution structure of Bacillus anthracis dihydrofolate reductase | 分子名称: | 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Deshmukh, L, Vinogradova, O, Beierlein, J.M, Frey, K.M, Anderson, A.C. | 登録日 | 2009-03-12 | 公開日 | 2009-05-12 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | The solution structure of Bacillus anthracis dihydrofolate reductase yields insight into the analysis of structure-activity relationships for novel inhibitors. Biochemistry, 48, 2009
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7LVC
| E. coli DHFR by Native Mn,P,S-SAD at Room Temperature | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | 著者 | Greisman, J.B, Dalton, K.M, Hekstra, D.R. | 登録日 | 2021-02-24 | 公開日 | 2021-03-17 | 最終更新日 | 2022-08-17 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Native SAD phasing at room temperature. Acta Crystallogr D Struct Biol, 78, 2022
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1U70
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8SSX
| Crystal structure of Bacillus anthracis dihydrofolate reductase at 1.65-A resolution | 分子名称: | 1,2-ETHANEDIOL, Dihydrofolate reductase, SULFATE ION | 著者 | Shaw, G.X, Li, Y, Wu, Y, Yan, H, Ji, X. | 登録日 | 2023-05-09 | 公開日 | 2023-05-17 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal structure of Bacillus anthracis dihydrofolate reductase at 1.65-A resolution To be published
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8SZE
| Crystal structure of Yersinia pestis dihydrofolate reductase in complex with Trimethoprim | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Dihydrofolate reductase, ... | 著者 | Shaw, G.X, Cherry, S, Tropea, J.E, Waugh, D.S, Ji, X. | 登録日 | 2023-05-29 | 公開日 | 2023-06-07 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of Yersinia pestis dihydrofolate reductase in complex with Trimethoprim To be published
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8SZD
| Crystal structure of Yersinia pestis dihydrofolate reductase at 1.25-A resolution | 分子名称: | CHLORIDE ION, Dihydrofolate reductase, MAGNESIUM ION, ... | 著者 | Shaw, G.X, Cherry, S, Tropea, J.E, Waugh, D.S, Ji, X. | 登録日 | 2023-05-29 | 公開日 | 2023-06-07 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Crystal structure of Yersinia pestis dihydrofolate reductase at 1.25-A resolution To be published
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7F3B
| cocrystallization of Escherichia coli dihydrofolate reductase (DHFR) and its pyrrolo[3,2-f]quinazoline inhibitor. | 分子名称: | 7-[(2-fluorophenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine, Dihydrofolate reductase, GLYCEROL | 著者 | Wang, H, You, X.F, Yang, X.Y, Li, Y, Hong, W. | 登録日 | 2021-06-16 | 公開日 | 2022-04-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates. Eur.J.Med.Chem., 228, 2022
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1U72
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