6XG5

X-ray structure of Escherichia coli dihydrofolate reductase in complex with trimethoprim

Summary for 6XG5

• Entry DOI: 10.2210/pdb6xg5/pdb
• Related: 1dre 1drh 1rh3 6xg4 7dfr
• Descriptor: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL, ... (6 entities in total)
• Functional Keywords: dihydrofolate reductase, dhfr, complex, trimethoprim, oxidoreductase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 20011.51

Authors

Gaszek, I.K.,Manna, M.S.,Borek, D.,Toprak, E. (deposition date: 2020-06-16, release date: 2021-03-24, Last modification date: 2023-10-18)

• Primary citation: Manna, M.S.,Tamer, Y.T.,Gaszek, I.,Poulides, N.,Ahmed, A.,Wang, X.,Toprak, F.C.R.,Woodard, D.R.,Koh, A.Y.,Williams, N.S.,Borek, D.,Atilgan, A.R.,Hulleman, J.D.,Atilgan, C.,Tambar, U.,Toprak, E.; A trimethoprim derivative impedes antibiotic resistance evolution.; Nat Commun, 12:2949-2949, 2021; PubMed: 34011959; DOI: 10.1038/s41467-021-23191-z

Experimental method

X-RAY DIFFRACTION (1.9 Å)