6XG5
X-ray structure of Escherichia coli dihydrofolate reductase in complex with trimethoprim
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dihydrofolate reductase | polymer | 165 | 18848.2 | 1 | UniProt (P0ABQ4) Pfam (PF00186) In PDB | Escherichia coli | |
2 | A | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
4 | A | TRIMETHOPRIM | non-polymer | 290.3 | 1 | Chemie (TOP) | |||
5 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
6 | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A: 1 - 159 (UniProt: P0ABQ4)
PDB | External Database | Details |
---|---|---|
His 160 | - | expression tag |
His 161 | - | expression tag |
His 162 | - | expression tag |
His 163 | - | expression tag |
His 164 | - | expression tag |
His 165 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 18848.2 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1163.3 | |
All* | Total formula weight | 20011.5 |