6VS6
Mycobacterium tuberculosis dihydrofolate reductase in complex with 3-(furan-2-yl)-1-methyl-1H-pyrazole-5-carboxylic acid (fragment 2)
Summary for 6VS6
| Entry DOI | 10.2210/pdb6vs6/pdb |
| Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, COBALT (II) ION, ... (6 entities in total) |
| Functional Keywords | folate pathway, biosynthetic protein |
| Biological source | Mycobacterium tuberculosis |
| Total number of polymer chains | 2 |
| Total formula weight | 37969.58 |
| Authors | Ribeiro, J.A.,Dias, M.V.B. (deposition date: 2020-02-10, release date: 2020-07-15, Last modification date: 2023-10-11) |
| Primary citation | Ribeiro, J.A.,Hammer, A.,Libreros-Zuniga, G.A.,Chavez-Pacheco, S.M.,Tyrakis, P.,de Oliveira, G.S.,Kirkman, T.,El Bakali, J.,Rocco, S.A.,Sforca, M.L.,Parise-Filho, R.,Coyne, A.G.,Blundell, T.L.,Abell, C.,Dias, M.V.B. Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase fromMycobacterium tuberculosis. Acs Infect Dis., 6:2192-2201, 2020 Cited by PubMed: 32603583DOI: 10.1021/acsinfecdis.0c00263 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.853 Å) |
Structure validation
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