3EEK

Candida glabrata Dihydrofolate Reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-(4-methylphenyl)phenyl)prop-1-ynyl]-6-methylpyrimidine(UCP111D4M) and NADPH

Summary for 3EEK

Entry DOI	10.2210/pdb3eek/pdb
Related	3EEJ 3EEL 3EEM
Descriptor	Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, ... (4 entities in total)
Functional Keywords	enzyme, oxidoreductase
Biological source	Candida glabrata (yeast)
Total number of polymer chains	2
Total formula weight	55090.44
Authors	Liu, J.,Anderson, A. (deposition date: 2008-09-04, release date: 2009-08-18, Last modification date: 2024-02-21)
Primary citation	Liu, J.,Bolstad, D.B.,Smith, A.E.,Priestley, N.D.,Wright, D.L.,Anderson, A.C. Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors Chem.Biol.Drug Des., 73:62-74, 2009 Cited by PubMed: 19152636 DOI: 10.1111/j.1747-0285.2008.00745.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation