7Z37
| Structure of the RAF1-HSP90-CDC37 complex (RHC-II) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ... | 著者 | Mesa, P, Garcia-Alonso, S, Barbacid, M, Montoya, G. | 登録日 | 2022-03-01 | 公開日 | 2022-09-14 | 最終更新日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.67 Å) | 主引用文献 | Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation. Mol.Cell, 82, 2022
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7Z38
| Structure of the RAF1-HSP90-CDC37 complex (RHC-I) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, Hsp90 co-chaperone Cdc37, ... | 著者 | Mesa, P, Garcia-Alonso, S, Barbacid, M, Montoya, G. | 登録日 | 2022-03-01 | 公開日 | 2022-09-14 | 最終更新日 | 2022-09-28 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation. Mol.Cell, 82, 2022
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7RY1
| human Hsp90_MC domain structure | 分子名称: | Heat shock protein HSP 90-alpha, N-[2-(1-MALEIMIDYL)ETHYL]-7-DIETHYLAMINOCOUMARIN-3-CARBOXAMIDE | 著者 | Peng, S, Deng, J, Matts, R. | 登録日 | 2021-08-24 | 公開日 | 2022-05-11 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.523 Å) | 主引用文献 | Crystal structure of the middle and C-terminal domains of Hsp90 alpha labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target. Acta Crystallogr D Struct Biol, 78, 2022
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7KRJ
| The GR-Maturation Complex: Glucocorticoid Receptor in complex with Hsp90 and co-chaperone p23 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... | 著者 | Noddings, C.M, Wang, Y.-R, Agard, D.A. | 登録日 | 2020-11-20 | 公開日 | 2022-01-12 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.56 Å) | 主引用文献 | Structure of Hsp90-p23-GR reveals the Hsp90 client-remodelling mechanism. Nature, 601, 2021
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7EXP
| Crystal structure of zebrafish TRAP1 with AMPPNP and MitoQ | 分子名称: | 2,3-dimethoxy-5-methyl-6-[10-(triphenyl-$l^{5}-phosphanyl)decyl]cyclohexa-2,5-diene-1,4-dione, COBALT (II) ION, MAGNESIUM ION, ... | 著者 | Lee, H, Yoon, N.G, Kang, B.H, Lee, C. | 登録日 | 2021-05-28 | 公開日 | 2022-01-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.297 Å) | 主引用文献 | Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site. J.Am.Chem.Soc., 143, 2021
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7KW7
| Atomic cryoEM structure of Hsp90-Hsp70-Hop-GR | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Glucocorticoid receptor, Heat shock 70 kDa protein 1A, ... | 著者 | Wang, R.Y, Noddings, C.M, Kirschke, E, Myasnikov, A, Johnson, J.L, Agard, D.A. | 登録日 | 2020-11-30 | 公開日 | 2021-12-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism. Nature, 601, 2022
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7KLV
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7KLU
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7KCL
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7KCM
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7KCK
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7L7J
| Cryo-EM structure of Hsp90:p23 closed-state complex | 分子名称: | Heat shock protein HSP 90-alpha, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Prostaglandin E synthase 3 | 著者 | Lee, K, Thwin, A.C, Tse, E, Gates, S.N, Southworth, D.R. | 登録日 | 2020-12-28 | 公開日 | 2021-08-25 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state. Mol.Cell, 81, 2021
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7L7I
| Cryo-EM structure of Hsp90:FKBP51:p23 closed-state complex | 分子名称: | Heat shock protein HSP 90-alpha, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Peptidyl-prolyl cis-trans isomerase FKBP5, ... | 著者 | Lee, K, Thwin, A.C, Tse, E, Gates, S.N, Southworth, D.R. | 登録日 | 2020-12-28 | 公開日 | 2021-08-25 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state. Mol.Cell, 81, 2021
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6XLE
| Full-length Hsc82 in complex with two Aha1 CTD in the presence of AMP-PNP | 分子名称: | ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, MAGNESIUM ION, ... | 著者 | Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A. | 登録日 | 2020-06-28 | 公開日 | 2021-06-30 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | 主引用文献 | Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1 To Be Published
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6XLC
| Full-length Hsc82 bound to AMPPNP | 分子名称: | ATP-dependent molecular chaperone HSC82, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A. | 登録日 | 2020-06-28 | 公開日 | 2021-06-30 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Full-length Hsc82 bound to AMPPNP To Be Published
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6XLB
| Apo full-length Hsc82 in complex with Aha1 | 分子名称: | ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1 | 著者 | Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A. | 登録日 | 2020-06-28 | 公開日 | 2021-06-30 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Apo full-length Hsc82 in complex with Aha1 To Be Published
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6XLG
| Full-length Hsc82 in complex with two Aha1 CTD in the presence of ATPgammaS | 分子名称: | ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, MAGNESIUM ION, ... | 著者 | Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A. | 登録日 | 2020-06-28 | 公開日 | 2021-06-30 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1 To Be Published
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6XLF
| Full-length Hsc82 in complex with Aha1 in the presence of AMP-PNP | 分子名称: | ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, MAGNESIUM ION, ... | 著者 | Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A. | 登録日 | 2020-06-28 | 公開日 | 2021-06-30 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1 To Be Published
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6XLH
| Asymmetric hydrolysis state of Hsc82 in complex with Aha1 bound with ADP and ATPgammaS | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, ... | 著者 | Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A. | 登録日 | 2020-06-28 | 公開日 | 2021-06-30 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1 To Be Published
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6XLD
| Full-length Hsc82 in complex with Aha1 CTD in the presence of AMPPNP | 分子名称: | ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1, MAGNESIUM ION, ... | 著者 | Liu, Y.X, Sun, M, Myasnikov, A.G, Elnatan, D, Agard, D.A. | 登録日 | 2020-06-28 | 公開日 | 2021-06-30 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Full-length Hsc82 in complex with Aha1 CTD in the presence of AMPPNP To Be Published
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7C7C
| Crystal structure of human TRAP1 with SJT104 | 分子名称: | 2-azanyl-9-[(4-bromanyl-2-fluoranyl-phenyl)methyl]-6-chloranyl-purin-8-ol, Heat shock protein 75 kDa, mitochondrial | 著者 | Kim, D, Yang, S, Yoon, N.G, Park, E, Kim, S.Y, Kang, B.H, Lee, C, Kang, S. | 登録日 | 2020-05-24 | 公開日 | 2021-05-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity. Acs Med.Chem.Lett., 12, 2021
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6XG6
| Full-length human mitochondrial Hsp90 (TRAP1) with ADP-BeF3 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Heat shock protein 75 kDa, ... | 著者 | Liu, Y.X, Wang, F, Agard, D.A. | 登録日 | 2020-06-17 | 公開日 | 2020-09-30 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM. Proc.Natl.Acad.Sci.USA, 117, 2020
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7C05
| Crystal structure of human Trap1 with DN203495 | 分子名称: | 1-[(4-bromanyl-2-fluoranyl-phenyl)methyl]-4-chloranyl-pyrazolo[3,4-d]pyrimidin-6-amine, Heat shock protein 75 kDa, mitochondrial | 著者 | Kim, D, Kim, D, Kim, S.Y, Lee, J.H, Kang, B.H, Kang, S, Lee, C. | 登録日 | 2020-04-30 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models. Bioorg.Chem., 101, 2020
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6KSQ
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6D14
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