7C7C

Crystal structure of human TRAP1 with SJT104

Summary for 7C7C

• Entry DOI: 10.2210/pdb7c7c/pdb
• Descriptor: Heat shock protein 75 kDa, mitochondrial, 2-azanyl-9-[(4-bromanyl-2-fluoranyl-phenyl)methyl]-6-chloranyl-purin-8-ol (2 entities in total)
• Functional Keywords: trpa1, selectivity, mitochondria, hsp90, anticancer, drug, chaperone
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 57794.67

Authors

Kim, D.,Yang, S.,Yoon, N.G.,Park, E.,Kim, S.Y.,Kang, B.H.,Lee, C.,Kang, S. (deposition date: 2020-05-24, release date: 2021-05-26, Last modification date: 2023-11-29)

• Primary citation: Yang, S.,Yoon, N.G.,Kim, D.,Park, E.,Kim, S.Y.,Lee, J.H.,Lee, C.,Kang, B.H.,Kang, S.; Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity.; Acs Med.Chem.Lett., 12:1173-1180, 2021; PubMed: 34267888; DOI: 10.1021/acsmedchemlett.1c00213

Experimental method

X-RAY DIFFRACTION (3 Å)