7KRJ

The GR-Maturation Complex: Glucocorticoid Receptor in complex with Hsp90 and co-chaperone p23

Summary for 7KRJ

• Entry DOI: 10.2210/pdb7krj/pdb
• EMDB information: 23004
• Descriptor: Heat shock protein HSP 90-alpha, Prostaglandin E synthase 3, Glucocorticoid receptor, ... (6 entities in total)
• Functional Keywords: ligand binding, atp binding, protein folding, cryo-em, chaperone
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 219664.15

Authors

Noddings, C.M.,Wang, Y.-R.,Agard, D.A. (deposition date: 2020-11-20, release date: 2022-01-12, Last modification date: 2022-01-26)

• Primary citation: Noddings, C.M.,Wang, R.Y.,Johnson, J.L.,Agard, D.A.; Structure of Hsp90-p23-GR reveals the Hsp90 client-remodelling mechanism.; Nature, 601:465-469, 2021; PubMed: 34937936; DOI: 10.1038/s41586-021-04236-1

Experimental method

ELECTRON MICROSCOPY (2.56 Å)