7KRJ
The GR-Maturation Complex: Glucocorticoid Receptor in complex with Hsp90 and co-chaperone p23
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Heat shock protein HSP 90-alpha | polymer | 732 | 84781.7 | 2 | UniProt (P07900) Pfam (PF13589) Pfam (PF00183) | Homo sapiens (Human) | Heat shock 86 kDa,HSP86,Lipopolysaccharide-associated protein 2,LPS-associated protein 2,Renal carcinoma antigen NY-REN-38 |
| 2 | C (C) | Prostaglandin E synthase 3 | polymer | 160 | 18720.4 | 1 | UniProt (Q15185) Pfam (PF04969) | Homo sapiens (Human) | Cytosolic prostaglandin E2 synthase,cPGES,Hsp90 co-chaperone,Progesterone receptor complex p23,Telomerase-binding protein p23 |
| 3 | D (D) | Glucocorticoid receptor | polymer | 258 | 29924.9 | 1 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (Human) | GR,Nuclear receptor subfamily 3 group C member 1 |
| 4 | E, G (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | F, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | I (D) | DEXAMETHASONE | non-polymer | 392.5 | 1 | Chemie (DEX) PubChem (16757640) PubChem (21140858) PubChem (3003) PubChem (176476476) PubChem (176476477) PubChem (176481066) PubChem (176519880) PubChem (176541415) PubChem (5743) PubChem (24758428) PubChem (24848023) PubChem (40467076) PubChem (40469527) PubChem (40469528) PubChem (40469529) PubChem (40469538) PubChem (40469540) PubChem (18609236) PubChem (46870667) PubChem (134645) PubChem (146915) PubChem (51529018) PubChem (51723203) PubChem (51723204) PubChem (53316140) PubChem (56627169) PubChem (40467075) PubChem (57959704) PubChem (57959709) PubChem (59499751) PubChem (59553041) PubChem (45791747) PubChem (60032782) PubChem (60107679) PubChem (60107685) PubChem (60113881) PubChem (60129028) PubChem (66739593) PubChem (67968282) PubChem (68163950) PubChem (68346426) PubChem (69301933) PubChem (70211292) PubChem (70834467) PubChem (70965822) PubChem (71083129) PubChem (51654720) PubChem (451600) PubChem (469455) PubChem (656865) PubChem (73707402) PubChem (73945193) PubChem (73950719) PubChem (1150209) PubChem (1426961) PubChem (68625576) PubChem (176476478) PubChem (3036635) PubChem (90141965) PubChem (9782) PubChem (155299) PubChem (71299643) PubChem (969487) PubChem (92043418) PubChem (92259599) PubChem (5702012) PubChem (6432476) PubChem (6546942) PubChem (6604243) PubChem (6603742) PubChem (124301806) PubChem (5702035) PubChem (92259552) PubChem (6610297) PubChem (6610335) PubChem (6710614) PubChem (117072391) PubChem (9830630) PubChem (9865316) PubChem (123132537) PubChem (124190915) PubChem (11014684) PubChem (124304345) PubChem (12358596) PubChem (12358597) PubChem (12358599) PubChem (12358600) PubChem (12358601) PubChem (12358603) PubChem (14697793) PubChem (124904342) PubChem (124904343) PubChem (124918510) PubChem (124918511) PubChem (129010233) PubChem (133634290) PubChem (133645861) PubChem (134990893) PubChem (135396701) PubChem (137704752) PubChem (139404989) PubChem (140662068) PubChem (145705940) PubChem (146436354) PubChem (152964101) PubChem (162730335) PubChem (163285078) PubChem (163285103) PubChem (164010962) PubChem (175434953) PubChem (176282643) |
Sequence modifications
D: 520 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Ser 602 | Phe 602 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 218208.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1455.4 | |
| All* | Total formula weight | 219664.1 |
