7KRJ
The GR-Maturation Complex: Glucocorticoid Receptor in complex with Hsp90 and co-chaperone p23
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Heat shock protein HSP 90-alpha | polymer | 732 | 84781.7 | 2 | UniProt (P07900) Pfam (PF13589) Pfam (PF00183) In PDB | Homo sapiens (Human) | Heat shock 86 kDa,HSP86,Lipopolysaccharide-associated protein 2,LPS-associated protein 2,Renal carcinoma antigen NY-REN-38 |
| 2 | C | Prostaglandin E synthase 3 | polymer | 160 | 18720.4 | 1 | UniProt (Q15185) Pfam (PF04969) In PDB | Homo sapiens (Human) | Cytosolic prostaglandin E2 synthase,cPGES,Hsp90 co-chaperone,Progesterone receptor complex p23,Telomerase-binding protein p23 |
| 3 | D | Glucocorticoid receptor | polymer | 258 | 29924.9 | 1 | UniProt (P04150) Pfam (PF00104) In PDB | Homo sapiens (Human) | GR,Nuclear receptor subfamily 3 group C member 1 |
| 4 | A, B | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | D | DEXAMETHASONE | non-polymer | 392.5 | 1 | Chemie (DEX) |
Sequence modifications
D: 520 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Ser 602 | Phe 602 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 218208.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1455.4 | |
| All* | Total formula weight | 219664.1 |
