6B0I
| Apo KLP10A in complex with a microtubule | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein Klp10A, ... | 著者 | Benoit, M.P.M.H, Asenjo, A.B, Sosa, H. | 登録日 | 2017-09-14 | 公開日 | 2018-05-02 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s. Nat Commun, 9, 2018
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6B30
| Structure of RORgt in complex with a novel inverse agonist 1 | 分子名称: | N-[(1R)-1-(4-methoxyphenyl)-2-oxo-2-{[4-(trimethylsilyl)phenyl]amino}ethyl]-N-methyl-3-oxo-2,3-dihydro-1,2-oxazole-5-carboxamide, Nuclear receptor ROR-gamma | 著者 | Skene, R.J, Hoffman, I. | 登録日 | 2017-09-20 | 公開日 | 2018-01-03 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Discovery of orally efficacious ROR gamma t inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds. Bioorg. Med. Chem., 26, 2018
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6CPI
| Solution structure of SH3 domain from Shank1 | 分子名称: | SH3 and multiple ankyrin repeat domains protein 1 | 著者 | Ishida, H, Vogel, H.J. | 登録日 | 2018-03-13 | 公開日 | 2018-08-15 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structures of the SH3 domains from Shank scaffold proteins and their interactions with Cav1.3 calcium channels. FEBS Lett., 592, 2018
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6CQE
| Crystal structure of HPK1 kinase domain S171A mutant | 分子名称: | Mitogen-activated protein kinase kinase kinase kinase 1 | 著者 | Wu, P, Lehoux, I, Mortara, K, Franke, Y, Wang, W. | 登録日 | 2018-03-15 | 公開日 | 2018-12-19 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.886 Å) | 主引用文献 | Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer. Structure, 27, 2019
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6CB5
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7RRW
| Monomeric CRM197 expressed in E. coli | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Diphtheria toxin | 著者 | Gallagher, D.T, Lees, A. | 登録日 | 2021-08-10 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Monomeric crystal structure of the vaccine carrier protein CRM 197 and implications for vaccine development. Acta Crystallogr.,Sect.F, 79, 2023
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7Q08
| Structure of Candida albicans 80S ribosome in complex with cycloheximide | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | 著者 | Zgadzay, Y, Kolosova, O, Stetsenko, A, Jenner, L, Guskov, A, Yusupova, G, Yusupov, M. | 登録日 | 2021-10-14 | 公開日 | 2022-05-25 | 最終更新日 | 2022-06-08 | 実験手法 | ELECTRON MICROSCOPY (2.56 Å) | 主引用文献 | E-site drug specificity of the human pathogen Candida albicans ribosome. Sci Adv, 8, 2022
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6VOS
| Crystal structure of macaque anti-HIV-1 antibody RM20J | 分子名称: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, HEXAETHYLENE GLYCOL, NONAETHYLENE GLYCOL, ... | 著者 | Yuan, M, Wilson, I.A. | 登録日 | 2020-01-31 | 公開日 | 2020-09-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.299 Å) | 主引用文献 | Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates. Plos Pathog., 16, 2020
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6CPK
| Solution structure of SH3 domain from Shank3 | 分子名称: | SH3 and multiple ankyrin repeat domains protein 3 | 著者 | Ishida, H, Vogel, H.J. | 登録日 | 2018-03-13 | 公開日 | 2018-08-15 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structures of the SH3 domains from Shank scaffold proteins and their interactions with Cav1.3 calcium channels. FEBS Lett., 592, 2018
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6TG8
| Crystal structure of the Kelch domain in complex with 11 amino acid peptide (model of the ETGE loop) | 分子名称: | Kelch-like ECH-associated protein 1, SODIUM ION, VAL-ILE-ASN-PRO-GLU-THR-GLY-GLU-GLN-ILE-GLN | 著者 | Kekez, I, Matic, S, Tomic, S, Matkovic-Calogovic, D. | 登録日 | 2019-11-15 | 公開日 | 2020-09-16 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Binding of dipeptidyl peptidase III to the oxidative stress cell sensor Kelch-like ECH-associated protein 1 is a two-step process. J.Biomol.Struct.Dyn., 39, 2021
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6TCK
| Crystal structure of the ATP binding domain of S. aureus GyrB complexed with ULD-2 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-[[3,4-bis(chloranyl)-5-methyl-1~{H}-pyrrol-2-yl]carbonylamino]-4-phenylmethoxy-1,3-benzothiazole-6-carboxylic acid, CALCIUM ION, ... | 著者 | Welin, M, Kimbung, R, Focht, D. | 登録日 | 2019-11-06 | 公開日 | 2020-09-23 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Rational design of balanced dual-targeting antibiotics with limited resistance. Plos Biol., 18, 2020
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7Q0R
| Structure of the Candida albicans 80S ribosome in complex with blasticidin s | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0, ... | 著者 | Kolosova, O, Zgadzay, Y, Stetsenko, A, Jenner, L, Guskov, A, Yusupova, G, Yusupov, M. | 登録日 | 2021-10-16 | 公開日 | 2022-05-25 | 最終更新日 | 2022-06-08 | 実験手法 | ELECTRON MICROSCOPY (2.67 Å) | 主引用文献 | E-site drug specificity of the human pathogen Candida albicans ribosome. Sci Adv, 8, 2022
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6CBF
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6VSR
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6VLR
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6VN0
| BG505 SOSIP.v4.1 in complex with rhesus macaque Fab RM20F | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | 著者 | Cottrell, C.A, Shin, M, Ward, A.B. | 登録日 | 2020-01-29 | 公開日 | 2020-06-24 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | 主引用文献 | Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates. Plos Pathog., 16, 2020
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6VOT
| Crystal structure of Pseudomonas aerugonisa PBP3 complexed to gamma-lactam YU253434 | 分子名称: | 1-[(2S)-2-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-oxopropyl]-4-{[2-(5,6 -dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamoyl}-2,5-dihydro-1H-pyrazole-3-carboxylic acid, Peptidoglycan D,D-transpeptidase FtsI | 著者 | van den Akker, F. | 登録日 | 2020-01-31 | 公開日 | 2020-05-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A gamma-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli. J.Med.Chem., 63, 2020
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6CBG
| Macrophage Migration Inhibitory Factor in Complex with a Pyrazole Inhibitor (5) | 分子名称: | 3-(1H-pyrazol-4-yl)benzoic acid, GLYCEROL, Macrophage migration inhibitory factor, ... | 著者 | Robertson, M.J, Krimmer, S.G, Jorgensen, W.L. | 登録日 | 2018-02-02 | 公開日 | 2018-04-04 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Optimization of Pyrazoles as Phenol Surrogates to Yield Potent Inhibitors of Macrophage Migration Inhibitory Factor. ChemMedChem, 13, 2018
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6CQF
| Crystal structure of HPK1 in complex an inhibitor G1858 | 分子名称: | Mitogen-activated protein kinase kinase kinase kinase 1, N-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3R)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1H-pyrazolo[4,3-c]pyridin-6-amine | 著者 | Wu, P, Lehoux, I, Mortara, K, Franke, Y, Chan, B.K, Wang, W. | 登録日 | 2018-03-15 | 公開日 | 2018-12-19 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.246 Å) | 主引用文献 | Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer. Structure, 27, 2019
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6VOR
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6VBP
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6CJK
| Anti HIV Fab 10A | 分子名称: | ACETATE ION, GLYCEROL, Immunoglobulin Fab heavy chain, ... | 著者 | Hangartner, L, Ward, A.B, Wilson, I.A, Oyen, D. | 登録日 | 2018-02-26 | 公開日 | 2018-08-15 | 最終更新日 | 2019-12-18 | 実験手法 | X-RAY DIFFRACTION (1.795 Å) | 主引用文献 | Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization. Immunity, 49, 2018
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6CBH
| Macrophage Migration Inhibitory Factor in Complex with a Pyrazole Inhibitor (8m) | 分子名称: | 5-(3-fluoro-1H-pyrazol-4-yl)-2-[(naphthalen-2-yl)oxy]benzoic acid, GLYCEROL, ISOPROPYL ALCOHOL, ... | 著者 | Robertson, M.J, Krimmer, S.G, Jorgensen, W.L. | 登録日 | 2018-02-02 | 公開日 | 2018-04-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Optimization of Pyrazoles as Phenol Surrogates to Yield Potent Inhibitors of Macrophage Migration Inhibitory Factor. ChemMedChem, 13, 2018
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6W69
| The structure of F64, S172A Keap1-BTB domain | 分子名称: | Kelch-like ECH-associated protein 1 | 著者 | Mena, E.L, Gee, C.L, Kuriyan, J, Rape, M. | 登録日 | 2020-03-16 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Structural basis for dimerization quality control. Nature, 586, 2020
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6W68
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