6CB5

Macrophage Migration Inhibitory Factor in complex with a Pyrazole Inhibitor (8g)

Summary for 6CB5

Entry DOI	10.2210/pdb6cb5/pdb
Descriptor	Macrophage migration inhibitory factor, 2-[(naphthalen-2-yl)oxy]-5-(1H-pyrazol-4-yl)benzoic acid, SULFATE ION, ... (4 entities in total)
Functional Keywords	cd74 binding, tautomerase, inhibitor, complex, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	38248.31
Authors	Krimmer, S.G.,Robertson, M.J.,Jorgensen, W.L. (deposition date: 2018-02-02, release date: 2018-04-04, Last modification date: 2023-10-04)
Primary citation	Trivedi-Parmar, V.,Robertson, M.J.,Cisneros, J.A.,Krimmer, S.G.,Jorgensen, W.L. Optimization of Pyrazoles as Phenol Surrogates to Yield Potent Inhibitors of Macrophage Migration Inhibitory Factor. ChemMedChem, 13:1092-1097, 2018 Cited by PubMed: 29575754 DOI: 10.1002/cmdc.201800158 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation