6VOT

Crystal structure of Pseudomonas aerugonisa PBP3 complexed to gamma-lactam YU253434

Summary for 6VOT

Entry DOI	10.2210/pdb6vot/pdb
Descriptor	Peptidoglycan D,D-transpeptidase FtsI, 1-[(2S)-2-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-oxopropyl]-4-{[2-(5,6 -dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamoyl}-2,5-dihydro-1H-pyrazole-3-carboxylic acid (3 entities in total)
Functional Keywords	inhibitor complex, penicillin-binding protein, antibiotic, hydrolase
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	1
Total formula weight	59018.08
Authors	van den Akker, F. (deposition date: 2020-01-31, release date: 2020-05-13, Last modification date: 2023-10-11)
Primary citation	Goldberg, J.A.,Nguyen, H.,Kumar, V.,Spencer, E.J.,Hoyer, D.,Marshall, E.K.,Cmolik, A.,O'Shea, M.,Marshall, S.H.,Hujer, A.M.,Hujer, K.M.,Rudin, S.D.,Domitrovic, T.N.,Bethel, C.R.,Papp-Wallace, K.M.,Logan, L.K.,Perez, F.,Jacobs, M.R.,van Duin, D.,Kreiswirth, B.M.,Bonomo, R.A.,Plummer, M.S.,van den Akker, F. A gamma-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli. J.Med.Chem., 63:5990-6002, 2020 Cited by PubMed: 32420736 DOI: 10.1021/acs.jmedchem.0c00255 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation