6VBP

Crystal structure of anti-HIV-1 antibody DH815 bound to gp120 V2 peptide

Summary for 6VBP

• Entry DOI: 10.2210/pdb6vbp/pdb
• Descriptor: DH815 light chain, DH815 heavy chain, Envelope glycoprotein gp160, ... (5 entities in total)
• Functional Keywords: antibody, gp120 v2, rv305/rv144, immune system, immune system-viral protein complex, immune system/viral protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 12
• Total formula weight: 202942.21

Authors

Janus, B.M.,Ofek, G. (deposition date: 2019-12-19, release date: 2020-02-12, Last modification date: 2023-10-11)

• Primary citation: Easterhoff, D.,Pollara, J.,Luo, K.,Janus, B.,Gohain, N.,Williams, L.D.,Tay, M.Z.,Monroe, A.,Peachman, K.,Choe, M.,Min, S.,Lusso, P.,Zhang, P.,Go, E.P.,Desaire, H.,Bonsignori, M.,Hwang, K.K.,Beck, C.,Kakalis, M.,O'Connell, R.J.,Vasan, S.,Kim, J.H.,Michael, N.L.,Excler, J.L.,Robb, M.L.,Rerks-Ngarm, S.,Kaewkungwal, J.,Pitisuttithum, P.,Nitayaphan, S.,Sinangil, F.,Tartaglia, J.,Phogat, S.,Wiehe, K.,Saunders, K.O.,Montefiori, D.C.,Tomaras, G.D.,Moody, M.A.,Arthos, J.,Rao, M.,Joyce, M.G.,Ofek, G.A.,Ferrari, G.,Haynes, B.F.; HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions.; JCI Insight, 5:-, 2020; PubMed: 31996483; DOI: 10.1172/jci.insight.131437

Experimental method

X-RAY DIFFRACTION (2.298 Å)