6VPP
| Cryo-EM structure of microtubule-bound KLP61F motor with tail domain in the nucleotide-free state | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein Klp61F, ... | 著者 | Bodrug, T, Wilson-Kubalek, E.M, Nithianantham, S, Debs, G, Sindelar, C.V, Milligan, R, Al-Bassam, J. | 登録日 | 2020-02-04 | 公開日 | 2020-02-19 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding. Elife, 9, 2020
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6VPO
| Cryo-EM structure of microtubule-bound KLP61F motor domain in the AMPPNP state | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein Klp61F, ... | 著者 | Bodrug, T, Wilson-Kubalek, E.M, Nithianantham, S, Debs, G, Sindelar, C.V, Milligan, R, Al-Bassam, J. | 登録日 | 2020-02-04 | 公開日 | 2020-02-19 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding. Elife, 9, 2020
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6LSN
| Crystal structure of tubulin-inhibitor complex | 分子名称: | 2-(1-methylindol-5-yl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Gang, L, Wang, Y.X, Cheng, J.J. | 登録日 | 2020-01-17 | 公開日 | 2021-01-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.445 Å) | 主引用文献 | Design, Synthesis, and Bioevaluation of Pyrazolo[1,5-a]Pyrimidine Derivatives as Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site with Potent Anticancer Activities To Be Published
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6LSM
| Tubulin Polymerization Inhibitors | 分子名称: | 2-(4-methylphenyl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Gang, L, Wang, Y.X, Chen, J.J. | 登録日 | 2020-01-17 | 公開日 | 2021-01-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.751 Å) | 主引用文献 | Design, Synthesis, and Bioevaluation of Pyrazolo[1,5-a]Pyrimidine Derivatives as Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site with Potent Anticancer Activities To Be Published
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6LS4
| A novel anti-tumor agent S-40 in complex with tubulin | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[(4-cyclopropylphenyl)sulfonylamino]-4-methyl-N-(pyridin-3-ylmethyl)benzamide, GLYCEROL, ... | 著者 | Du, T, Lin, S, Ji, M, Xue, N, Liu, Y, Zhang, K, Lu, D, Chen, X, Xu, H. | 登録日 | 2020-01-17 | 公開日 | 2021-01-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity. Cancer Lett., 495, 2020
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6VE7
| The inner junction complex of Chlamydomonas reinhardtii doublet microtubule | 分子名称: | Cilia- and flagella-associated protein 20, FAP276, FAP52, ... | 著者 | Khalifa, A.A.Z, Ichikawa, M, Bui, K.H. | 登録日 | 2019-12-30 | 公開日 | 2020-02-05 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications. Elife, 9, 2020
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6LL5
| Crystal structure of KpFtsZ (residues 11-316) | 分子名称: | Cell division protein FtsZ, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE | 著者 | Yoshizawa, T, Fujita, J, Terakado, H, Ozawa, M, Kuroda, N, Tanaka, S, Uehara, R, Matsumura, H. | 登録日 | 2019-12-21 | 公開日 | 2020-02-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal structures of the cell-division protein FtsZ from Klebsiella pneumoniae and Escherichia coli. Acta Crystallogr.,Sect.F, 76, 2020
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6LL6
| Crsyal structure of EcFtsZ (residues 11-316) | 分子名称: | Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE | 著者 | Yoshizawa, T, Fujita, J, Terakada, H, Ozawa, M, Kuroda, N, Tanaka, S, Uehara, R, Matsumura, H. | 登録日 | 2019-12-21 | 公開日 | 2020-02-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structures of the cell-division protein FtsZ from Klebsiella pneumoniae and Escherichia coli. Acta Crystallogr.,Sect.F, 76, 2020
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6V6S
| Structure of the native human gamma-tubulin ring complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Gamma-tubulin complex component 2, ... | 著者 | Wieczorek, M, Urnavicius, L, Ti, S, Molloy, K.R, Chait, B.T, Kapoor, T.M. | 登録日 | 2019-12-05 | 公開日 | 2020-01-01 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Asymmetric Molecular Architecture of the Human gamma-Tubulin Ring Complex. Cell, 180, 2020
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6V5V
| Structure of gamma-tubulin in the native human gamma-tubulin ring complex | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Tubulin gamma-1 chain | 著者 | Wieczorek, M, Urnavicius, L, Ti, S, Molloy, K.R, Chait, B.T, Kapoor, T.M. | 登録日 | 2019-12-04 | 公開日 | 2020-01-01 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Asymmetric Molecular Architecture of the Human gamma-Tubulin Ring Complex. Cell, 180, 2020
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6TIW
| Human kinesin-5 motor domain in the GSK state bound to microtubules (Conformation 2) | 分子名称: | 6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1~{H}-quinolin-2-one, Kinesin-like protein KIF11, MAGNESIUM ION, ... | 著者 | Pena, A, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M. | 登録日 | 2019-11-22 | 公開日 | 2020-03-04 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy. Structure, 28, 2020
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6TIS
| DROSOPHILA GDP-TUBULIN | 分子名称: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Gigant, B. | 登録日 | 2019-11-22 | 公開日 | 2021-01-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation. J.Cell Biol., 220, 2021
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6TIY
| DROSOPHILA GMPCPP-TUBULIN | 分子名称: | GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Gigant, B. | 登録日 | 2019-11-22 | 公開日 | 2021-01-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.293 Å) | 主引用文献 | GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation. J.Cell Biol., 220, 2021
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6TIZ
| DROSOPHILA GDP-TUBULIN Y222F MUTANT | 分子名称: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Gigant, B. | 登録日 | 2019-11-22 | 公開日 | 2021-01-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.197 Å) | 主引用文献 | GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation. J.Cell Biol., 220, 2021
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6TIU
| DROSOPHILA GTP-TUBULIN Y222F MUTANT | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Gigant, B. | 登録日 | 2019-11-22 | 公開日 | 2021-01-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.571 Å) | 主引用文献 | GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation. J.Cell Biol., 220, 2021
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6TF9
| Structure of the vertebrate gamma-Tubulin Ring Complex | 分子名称: | Actin, cytoplasmic 1, Belt helices 1,2,3,4, ... | 著者 | Zupa, E, Pfeffer, S. | 登録日 | 2019-11-13 | 公開日 | 2019-12-11 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Insights into the assembly and activation of the microtubule nucleator gamma-TuRC. Nature, 578, 2020
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6TDE
| Tubulin-inhibitor complex | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Varela, P.F, Gigant, B. | 登録日 | 2019-11-08 | 公開日 | 2020-09-02 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.286 Å) | 主引用文献 | Discovery of dihydrofuranoallocolchicinoids - Highly potent antimitotic agents with low acute toxicity. Eur.J.Med.Chem., 207, 2020
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6TA4
| Human kinesin-5 motor domain in the AMPPNP state bound to microtubules | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF11, MAGNESIUM ION, ... | 著者 | Pena, A.P, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M. | 登録日 | 2019-10-29 | 公開日 | 2020-03-04 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy. Structure, 28, 2020
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6TA3
| Human kinesin-5 motor domain in the GSK-1 state bound to microtubules (Conformation 1) | 分子名称: | 6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1~{H}-quinolin-2-one, Kinesin-like protein KIF11, MAGNESIUM ION, ... | 著者 | Pena, A, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M. | 登録日 | 2019-10-29 | 公開日 | 2020-04-22 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy. Structure, 28, 2020
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6UNX
| Structure of E. coli FtsZ(L178E)-GTP complex | 分子名称: | Cell division protein FtsZ, GUANOSINE-5'-TRIPHOSPHATE | 著者 | Schumacher, M.A. | 登録日 | 2019-10-13 | 公開日 | 2020-02-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | High-resolution crystal structures of Escherichia coli FtsZ bound to GDP and GTP. Acta Crystallogr.,Sect.F, 76, 2020
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6UMK
| Structure of E. coli FtsZ(L178E)-GDP complex | 分子名称: | Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE | 著者 | Schumacher, M.A. | 登録日 | 2019-10-09 | 公開日 | 2020-02-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | High-resolution crystal structures of Escherichia coli FtsZ bound to GDP and GTP. Acta Crystallogr.,Sect.F, 76, 2020
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6KVQ
| S. aureus FtsZ in complex with BOFP (compound 3) | 分子名称: | CALCIUM ION, Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Ferrer-Gonzalez, E, Fujita, J, Yoshizawa, T, Nelson, J.M, Pilch, A.J, Hillman, E, Ozawa, M, Kuroda, N, Parhi, A.K, LaVoie, E.J, Matsumura, H, Pilch, D.S. | 登録日 | 2019-09-05 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure-Guided Design of a Fluorescent Probe for the Visualization of FtsZ in Clinically Important Gram-Positive and Gram-Negative Bacterial Pathogens. Sci Rep, 9, 2019
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6KVP
| S. aureus FtsZ in complex with 3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethoxy)-2,6-difluorobenzamide (compound 2) | 分子名称: | 3-[(1R)-1-[5-bromanyl-4-[4-(trifluoromethyl)phenyl]-1,3-oxazol-2-yl]ethoxy]-2,6-bis(fluoranyl)benzamide, CALCIUM ION, Cell division protein FtsZ, ... | 著者 | Ferrer-Gonzalez, E, Fujita, J, Yoshizawa, T, Nelson, J.M, Pilch, A.J, Hillman, E, Ozawa, M, Kuroda, N, Parhi, A.K, LaVoie, E.J, Matsumura, H, Pilch, D.S. | 登録日 | 2019-09-05 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structure-Guided Design of a Fluorescent Probe for the Visualization of FtsZ in Clinically Important Gram-Positive and Gram-Negative Bacterial Pathogens. Sci Rep, 9, 2019
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6U42
| Natively decorated ciliary doublet microtubule | 分子名称: | DC1, DC2, DC3, ... | 著者 | Ma, M, Stoyanova, M, Rademacher, G, Dutcher, S.K, Brown, A, Zhang, R. | 登録日 | 2019-08-22 | 公開日 | 2019-11-13 | 最終更新日 | 2020-01-08 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure of the Decorated Ciliary Doublet Microtubule. Cell, 179, 2019
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6KPP
| BNC105 in complex with tubulin | 分子名称: | (6-methoxy-2-methyl-7-oxidanyl-1-benzofuran-3-yl)-(3,4,5-trimethoxyphenyl)methanone, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Wang, T, Wu, C, Pu, D. | 登録日 | 2019-08-15 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.74524117 Å) | 主引用文献 | Unraveling the molecular mechanism of BNC105, a phase II clinical trial vascular disrupting agent, provides insights into drug design. Biochem.Biophys.Res.Commun., 2020
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