6TA4

Human kinesin-5 motor domain in the AMPPNP state bound to microtubules

Summary for 6TA4

• Entry DOI: 10.2210/pdb6ta4/pdb
• EMDB information: 10422
• Descriptor: Tubulin beta chain, Tubulin alpha-1B chain, Kinesin-like protein KIF11, ... (7 entities in total)
• Functional Keywords: kinesin, microtubule, mitosis, inhibition, motor, cell cycle
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 142244.21

Authors

Pena, A.P.,Sweeney, A.,Cook, A.D.,Moores, C.A.,Topf, M. (deposition date: 2019-10-29, release date: 2020-03-04, Last modification date: 2020-04-15)

• Primary citation: Pena, A.,Sweeney, A.,Cook, A.D.,Topf, M.,Moores, C.A.; Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy.; Structure, 28:450-457.e5, 2020; PubMed: 32084356; DOI: 10.1016/j.str.2020.01.013

Experimental method

ELECTRON MICROSCOPY (6.1 Å)