6VPP

Cryo-EM structure of microtubule-bound KLP61F motor with tail domain in the nucleotide-free state

Summary for 6VPP

Entry DOI	10.2210/pdb6vpp/pdb
EMDB information	21314 21315
Descriptor	Tubulin alpha-1A chain, Tubulin beta chain, Kinesin-like protein Klp61F, ... (6 entities in total)
Functional Keywords	kinesin-5, klp61f, microtubules, mitotic spindles, nucleotide-free state, cell cycle, motor protein
Biological source	Drosophila melanogaster (Fruit fly) More
Total number of polymer chains	3
Total formula weight	143647.06
Authors	Bodrug, T.,Wilson-Kubalek, E.M.,Nithianantham, S.,Debs, G.,Sindelar, C.V.,Milligan, R.,Al-Bassam, J. (deposition date: 2020-02-04, release date: 2020-02-19, Last modification date: 2024-03-06)
Primary citation	Bodrug, T.,Wilson-Kubalek, E.M.,Nithianantham, S.,Thompson, A.F.,Alfieri, A.,Gaska, I.,Major, J.,Debs, G.,Inagaki, S.,Gutierrez, P.,Gheber, L.,McKenney, R.J.,Sindelar, C.V.,Milligan, R.,Stumpff, J.,Rosenfeld, S.S.,Forth, S.T.,Al-Bassam, J. The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding. Elife, 9:-, 2020 Cited by PubMed: 31958056 DOI: 10.7554/eLife.51131 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.4 Å)

Structure validation