6TIW

Human kinesin-5 motor domain in the GSK state bound to microtubules (Conformation 2)

Summary for 6TIW

Entry DOI	10.2210/pdb6tiw/pdb
EMDB information	10421
Descriptor	Kinesin-like protein KIF11, Tubulin beta chain, Tubulin alpha-1B chain, ... (6 entities in total)
Functional Keywords	kinesin, microtubule, mitosis, inhibition, motor, cell cycle
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	142003.00
Authors	Pena, A.,Sweeney, A.,Cook, A.D.,Moores, C.A.,Topf, M. (deposition date: 2019-11-22, release date: 2020-03-04, Last modification date: 2024-05-15)
Primary citation	Pena, A.,Sweeney, A.,Cook, A.D.,Topf, M.,Moores, C.A. Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy. Structure, 28:450-457.e5, 2020 Cited by PubMed: 32084356 DOI: 10.1016/j.str.2020.01.013 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.8 Å)

Structure validation