6TIW

Human kinesin-5 motor domain in the GSK state bound to microtubules (Conformation 2)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (K)	Kinesin-like protein KIF11	polymer	391	43727.5	1	UniProt (P52732) Pfam (PF00225)	Homo sapiens (Human)	Kinesin-like protein 1,Kinesin-like spindle protein HKSP,Kinesin-related motor protein Eg5,Thyroid receptor-interacting protein 5,TRIP-5
2	B (B)	Tubulin beta chain	polymer	429	48113.1	1	UniProt (P02554) Pfam (PF00091) Pfam (PF03953)	Sus scrofa (Pig)	Beta-tubulin
3	C (A)	Tubulin alpha-1B chain	polymer	438	48780.1	1	UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953)	Sus scrofa (Pig)	Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
4	D (K)	6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1~{H}-quinolin-2-one	non-polymer		291.3	1	Chemie (MZK)
5	E, G (B, A)	PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER	non-polymer		521.2	2	Chemie (G2P)
6	F, H (B, A)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)

Sequence modifications

K: 1 - 369 (UniProt: P52732)

PDB	External Database	Details
Met -21	-	initiating methionine
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	140620.7
Non-Polymers*	Number of molecules	5
	Total formula weight	1382.3
All*	Total formula weight	142003.0

*Water molecules are not included.