6LSN

Crystal structure of tubulin-inhibitor complex

Summary for 6LSN

• Entry DOI: 10.2210/pdb6lsn/pdb
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-(1-methylindol-5-yl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine, ... (13 entities in total)
• Functional Keywords: inhibitor, cell cycle
• Biological source: Sus scrofa (Pig); More
• Total number of polymer chains: 6
• Total formula weight: 264889.47

Authors

Gang, L.,Wang, Y.X.,Cheng, J.J. (deposition date: 2020-01-17, release date: 2021-01-20, Last modification date: 2023-11-29)

• Primary citation: Gang, L.,Wang, Y.X.,Chen, J.J.; Design, Synthesis, and Bioevaluation of Pyrazolo[1,5-a]Pyrimidine Derivatives as Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site with Potent Anticancer Activities; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.445 Å)