6KPP

BNC105 in complex with tubulin

Summary for 6KPP

Entry DOI	10.2210/pdb6kpp/pdb
Descriptor	Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, ... (12 entities in total)
Functional Keywords	bnc105, tubulin, protein-drug complex, antitumor protein
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	6
Total formula weight	264734.52
Authors	Wang, T.,Wu, C.,Pu, D. (deposition date: 2019-08-15, release date: 2020-08-19, Last modification date: 2023-11-22)
Primary citation	Wang, T.,Wu, C.,Wang, C.,Zhang, G.,Arnst, K.E.,Yao, Y.,Zhang, Z.,Wang, Y.,Pu, D.,Li, W. Unraveling the molecular mechanism of BNC105, a phase II clinical trial vascular disrupting agent, provides insights into drug design. Biochem.Biophys.Res.Commun., 2020 Cited by PubMed: 32085900 DOI: 10.1016/j.bbrc.2019.12.083 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.74524106157 Å)

Structure validation