PDB: 435 件ウェブページステータス検索Chemie searchBIRD

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7ELJ	Prion Derived Tetrapeptide Stabilizes Thermolabile Insulin via Conformational Trapping 分子名称: IS1, Insulin A Chain, Insulin B chain 著者 Banerjee, N. 登録日 2021-04-11 公開日 2021-04-28 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Prion-derived tetrapeptide stabilizes thermolabile insulin via conformational trapping. Iscience, 24, 2021
7INS	STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z 分子名称: GENERAL PROTAMINE CHAIN, INSULIN (CHAIN A), INSULIN (CHAIN B), ... 著者 Balschmidt, P, Hansen, F.B, Dodson, E, Dodson, G, Korber, F. 登録日 1991-09-03 公開日 1994-01-31 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of porcine insulin cocrystallized with clupeine Z. Acta Crystallogr.,Sect.B, 47, 1991
7JP3	Des-B29,B30-insulin 分子名称: CHLORIDE ION, Insulin B chain,Insulin A chain, PHENOL, ... 著者 Yoder, J, Weiss, M.A, DiMarchi, R, Zaykov, A. 登録日 2020-08-07 公開日 2021-10-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Des-B29,B30-insulin To Be Published
7KD6	Insulin Receptor L1-CR plus alphaCT fragment in co-complex with Fv 83-7 and single-chain insulin SCI-b 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Lawrence, M.C, Menting, J.G. 登録日 2020-10-08 公開日 2021-10-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Single-chain insulin analogs threaded by the insulin receptor alpha CT domain. Biophys.J., 2022
7MD4	Insulin receptor ectodomain dimer complexed with two IRPA-3 partial agonists 分子名称: Insulin B chain, Insulin chain A, Isoform Short of Insulin receptor, ... 著者 Gomez-Llorente, Y, Zhou, H, Scapin, G. 登録日 2021-04-03 公開日 2022-02-23 最終更新日 2022-03-02 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists. Nat Commun, 13, 2022
7MD5	Insulin receptor ectodomain dimer complexed with two IRPA-9 partial agonists 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Gomez-Llorente, Y, Zhou, H, Scapin, G. 登録日 2021-04-03 公開日 2022-02-23 最終更新日 2022-03-02 実験手法 ELECTRON MICROSCOPY (5.2 Å) 主引用文献 Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists. Nat Commun, 13, 2022
7NHU	Crystal structure of desB30 insulin produced by cell free protein synthesis 分子名称: Insulin 著者 Johansson, E. 登録日 2021-02-11 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Cell free protein synthesis versus yeast expression - A comparison using insulin as a model protein. Protein Expr.Purif., 186, 2021
7PG0	Low resolution Cryo-EM structure of full-length insulin receptor bound to 3 insulin with visible ddm micelle, conf 1 分子名称: Insulin, Isoform Short of Insulin receptor 著者 Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P. 登録日 2021-08-12 公開日 2022-02-02 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (7.6 Å) 主引用文献 Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling. J.Mol.Biol., 434, 2022
7PG2	Low resolution Cryo-EM structure of full-length insulin receptor bound to 3 insulin, conf 1 分子名称: Insulin, Isoform Short of Insulin receptor 著者 Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P. 登録日 2021-08-12 公開日 2022-02-02 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (6.7 Å) 主引用文献 Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling. J.Mol.Biol., 434, 2022
7PG3	Low resolution Cryo-EM structure of the full-length insulin receptor bound to 3 insulin, conf 2 分子名称: Insulin, Isoform Short of Insulin receptor 著者 Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P. 登録日 2021-08-12 公開日 2022-02-02 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (7.3 Å) 主引用文献 Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling. J.Mol.Biol., 434, 2022
7PG4	Low resolution Cryo-EM structure of the full-length insulin receptor bound to 2 insulin, conf 3 分子名称: Insulin, Isoform Short of Insulin receptor 著者 Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P. 登録日 2021-08-12 公開日 2022-02-02 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (9.1 Å) 主引用文献 Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling. J.Mol.Biol., 434, 2022
7QAC	The T2 structure of polycrystalline cubic human insulin 分子名称: Insulin A chain, Insulin B chain 著者 Karavassili, F, Triandafillidis, D.P, Valmas, A, Spiliopoulou, M, Fili, S, Kontou, P, Bowler, M.W, Von Dreele, R.B, Fitch, A, Margiolaki, I. 登録日 2021-11-16 公開日 2023-06-21 最終更新日 2024-02-07 実験手法 POWDER DIFFRACTION (2.29 Å) 主引用文献 The T 2 structure of polycrystalline cubic human insulin. Acta Crystallogr D Struct Biol, 79, 2023
7QGF	Cubic Insulin SAD phasing at 14.2 keV 分子名称: Insulin A chain, Insulin B chain 著者 Nanao, M.H, Basu, S. 登録日 2021-12-08 公開日 2022-06-01 実験手法 X-RAY DIFFRACTION (1.203 Å) 主引用文献 ID23-2: an automated and high-performance microfocus beamline for macromolecular crystallography at the ESRF. J.Synchrotron Radiat., 29, 2022
7QID	tentative model of the human insulin receptor ectodomain bound by three insulin 分子名称: Insulin, Insulin receptor, Isoform Short of Insulin receptor 著者 Gutman, T, Schaefer, I.B, Poojari, C.S, Vattulainen, I, Strauss, M, Coskun, U. 登録日 2021-12-14 公開日 2022-02-02 実験手法 ELECTRON MICROSCOPY (5 Å) 主引用文献 Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain J Cell Biol, 219, 2020
7RKD	X-Ray structure of Insulin Analog GLULISINE 分子名称: Insulin B chain analog, Insulin chain A, ZINC ION 著者 Reyes-Grajeda, J.P. 登録日 2021-07-22 公開日 2022-07-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Insulin ANALOGS To Be Published
7RZE	Insulin Degrading Enzyme pO/pC 分子名称: Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain 著者 Mancl, J.M, Liang, W.G, Tang, W.J. 登録日 2021-08-27 公開日 2022-08-31 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
7RZF	Insulin Degrading Enzyme O/pC 分子名称: Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain 著者 Mancl, J.M, Liang, W.G, Tang, W.J. 登録日 2021-08-27 公開日 2022-08-31 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
7RZI	Insulin Degrading Enzyme pC/pC 分子名称: Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain 著者 Mancl, J.M, Liang, W.G, Tang, W.J. 登録日 2021-08-27 公開日 2022-08-31 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme To be published
7S0Q	Head region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ... 著者 Xu, Y, Lawrence, M.C. 登録日 2021-08-30 公開日 2022-07-06 最終更新日 2022-08-17 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor. Structure, 30, 2022
7S4Y	Serial Macromolecular Crystallography at ALBA Synchrotron Light Source - Insulin 分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ... 著者 Martin-Garcia, J.M, Botha, S, Hu, H, Jernigan, R, Castellvi, A, Lisova, S, Gil, F, Calisto, B, Crespo, I, Roy-Chowdbury, S, Grieco, A, Ketawala, G, Weierstall, U, Spence, J, Fromme, P, Zatsepin, N, Boer, R, Carpena, X. 登録日 2021-09-09 公開日 2021-10-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Serial macromolecular crystallography at ALBA Synchrotron Light Source. J.Synchrotron Radiat., 29, 2022
7SL1	Full-length insulin receptor bound with site 1 binding deficient mutant insulin (A-V3E) 分子名称: Insulin A chain, Insulin B chain, Insulin receptor 著者 Bai, X.C, Choi, E. 登録日 2021-10-22 公開日 2022-03-30 最終更新日 2022-04-27 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL2	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R) -- asymmetric conformation 分子名称: Insulin A chain, Insulin B chain, Insulin receptor 著者 Bai, X.C, Choi, E. 登録日 2021-10-22 公開日 2022-03-30 最終更新日 2022-04-27 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL3	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R) -- symmetric conformation 分子名称: Insulin A chain, Insulin B chain, Insulin receptor 著者 Bai, X.C, Choi, E. 登録日 2021-10-22 公開日 2022-03-30 最終更新日 2022-04-27 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL4	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- asymmetric conformation 分子名称: Insulin A chain, Insulin B chain, Insulin receptor 著者 Bai, X.C, Choi, E. 登録日 2021-10-22 公開日 2022-03-30 最終更新日 2022-04-27 実験手法 ELECTRON MICROSCOPY (5 Å) 主引用文献 Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL6	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- symmetric conformation 分子名称: Insulin A chain, Insulin B chain, Insulin receptor 著者 Bai, X.C, Choi, E. 登録日 2021-10-22 公開日 2022-03-30 最終更新日 2022-04-27 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022

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