PDB: 4939 件ウェブページステータス検索Chemie searchBIRD

---

2G9X	Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271 分子名称: 3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL, Cell division protein kinase 2, Cyclin-A2 著者 Echalier, A, Endicott, J.A, Noble, M.E. 登録日 2006-03-07 公開日 2006-05-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination. J.Am.Chem.Soc., 128, 2006
4WBO	Bovine G Protein Coupled Receptor Kinase 1 in Complex with Amlexanox 分子名称: 2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid, CHLORIDE ION, Rhodopsin kinase 著者 Homan, K.T, Tesmer, J.J.G. 登録日 2014-09-03 公開日 2014-11-05 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Identification and characterization of amlexanox as a g protein-coupled receptor kinase 5 inhibitor. Molecules, 19, 2014
8E06	Symmetry expansion of dimeric LRRK1 分子名称: GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 1 著者 Reimer, J.M, Lin, Y.X, Leschziner, A.E. 登録日 2022-08-08 公開日 2023-08-30 最終更新日 2023-11-29 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structure of LRRK1 and mechanisms of autoinhibition and activation. Nat.Struct.Mol.Biol., 30, 2023
8E04	Structure of monomeric LRRK1 分子名称: GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 1 著者 Reimer, J.M, Mathea, S, Chatterjee, D, Knapp, S, Leschziner, A.E. 登録日 2022-08-08 公開日 2023-08-30 最終更新日 2023-11-29 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structure of LRRK1 and mechanisms of autoinhibition and activation. Nat.Struct.Mol.Biol., 30, 2023
8E05	Structure of dimeric LRRK1 分子名称: GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 1 著者 Reimer, J.M, Lin, Y.X, Leschziner, A.E. 登録日 2022-08-08 公開日 2023-08-30 最終更新日 2023-11-29 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Structure of LRRK1 and mechanisms of autoinhibition and activation. Nat.Struct.Mol.Biol., 30, 2023
4OTI	Crystal Structure of PRK1 Catalytic Domain in Complex with Tofacitinib 分子名称: 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile, Serine/threonine-protein kinase N1 著者 Chamberlain, P.P, Delker, S, Pagarigan, B, Mahmoudi, A, Jackson, P, Abbassian, M, Muir, J, Raheja, N, Cathers, B. 登録日 2014-02-13 公開日 2014-08-27 最終更新日 2018-01-24 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes. Plos One, 9, 2014
4OR5	Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4 分子名称: AF4/FMR2 family member 4, Cyclin-T1, Cyclin-dependent kinase 9, ... 著者 Gu, J, Babayeva, N.D, Suwa, Y, Baranovskiy, A.G, Price, D.H, Tahirov, T.H. 登録日 2014-02-10 公開日 2014-04-16 最終更新日 2014-06-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4. Cell Cycle, 13, 2014
4ONA	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1517 分子名称: 5-amino-1-tert-butyl-3-(7-ethoxyquinolin-3-yl)-1H-pyrazole-4-carboxamide, Calmodulin-domain protein kinase 1 著者 Merritt, E.A. 登録日 2014-01-28 公開日 2014-03-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. ACS Med Chem Lett, 5, 2014
5KCV	Crystal structure of allosteric inhibitor, ARQ 092, in complex with autoinhibited form of AKT1 分子名称: 3-[3-[4-(1-azanylcyclobutyl)phenyl]-5-phenyl-imidazo[4,5-b]pyridin-2-yl]pyridin-2-amine, RAC-alpha serine/threonine-protein kinase 著者 Eathiraj, S. 登録日 2016-06-07 公開日 2016-06-29 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor. J.Med.Chem., 59, 2016
3UPZ	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumpless BKI analog UW1243 分子名称: 1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1 著者 Merritt, E.A, Larson, E.T. 登録日 2011-11-18 公開日 2012-03-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012
3V5W	Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine 分子名称: G-protein coupled receptor kinase 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Thal, D.M, Tesmer, J.J.G. 登録日 2011-12-17 公開日 2012-09-26 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. Acs Chem.Biol., 7, 2012
5KKR	KSR2:MEK1 Complex Bound to the Small Molecule APS-2-79 分子名称: 6,7-dimethoxy-~{N}-(2-methyl-4-phenoxy-phenyl)quinazolin-4-amine, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2 著者 Dhawan, N.S, Scopton, A.P, Dar, A.C. 登録日 2016-06-22 公開日 2016-08-31 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.509 Å) 主引用文献 Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature, 537, 2016
3UJG	Crystal structure of SnRK2.6 in complex with HAB1 分子名称: MAGNESIUM ION, Protein phosphatase 2C 16, SULFATE ION, ... 著者 Zhou, X.E, Soon, F.-F, Ng, L.-M, Kovach, A, Tan, M.H.E, Suino-Powell, K.M, He, Y, Xu, Y, Brunzelle, J.S, Li, J, Melcher, K, Xu, H.E. 登録日 2011-11-07 公開日 2012-02-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science, 335, 2012
3V5T	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1299 分子名称: 1-[(2S)-2-(dimethylamino)-3-methylbutyl]-3-(6-ethoxynaphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1 著者 Merritt, E.A, Larson, E.T. 登録日 2011-12-16 公開日 2012-03-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012
5KQ5	AMPK bound to allosteric activator 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Calabrese, M.F, Kurumbail, R.G. 登録日 2016-07-05 公開日 2016-08-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.41 Å) 主引用文献 Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. J.Med.Chem., 59, 2016
5L8J	Aurora-A kinase domain in complex with vNAR-D01 S93R 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ... 著者 Burgess, S.G, Bayliss, R. 登録日 2016-06-08 公開日 2016-07-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain. Open Biology, 6, 2016
5CYZ	Structure of S. cerevisiae Hrr25:Mam1 complex, form 1 分子名称: Casein kinase I homolog HRR25, Monopolin complex subunit MAM1, ZINC ION 著者 Ye, Q, Corbett, K.D. 登録日 2015-07-31 公開日 2016-08-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.841 Å) 主引用文献 Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator. Embo J., 35, 2016
5D9K	Rsk2 N-terminal Kinase in Complex with BI-D1870 分子名称: (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one, GLYCEROL, Ribosomal protein S6 kinase alpha-3 著者 Appleton, B.A. 登録日 2015-08-18 公開日 2015-09-02 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Discovery of Potent and Selective RSK Inhibitors as Biological Probes. J.Med.Chem., 58, 2015
5DFZ	Structure of Vps34 complex II from S. cerevisiae. 分子名称: Nanobody binding S. cerevisiae Vps34, Phosphatidylinositol 3-kinase VPS34, Putative N-terminal domain of S. cerevisiae Vps30, ... 著者 Rostislavleva, K, Soler, N, Ohashi, Y, Zhang, L, Williams, R.L. 登録日 2015-08-27 公開日 2015-10-07 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (4.4 Å) 主引用文献 Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes. Science, 350, 2015
5DVR	Crystal Structure of TgCDPK1 From Toxoplasma Gondii complexed with GW780159X 分子名称: 4-(3-chlorophenyl)-5-(1,5-naphthyridin-2-yl)-1,3-thiazol-2-amine, Calmodulin-domain protein kinase 1, UNKNOWN ATOM OR ION 著者 Jiang, D.Q, Tempel, W, Loppnau, P, Graslund, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Lovato, D.V, Osman, K.T, Structural Genomics Consortium (SGC) 登録日 2015-09-21 公開日 2015-09-30 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of TgCDPK1 From Toxoplasma Gondii complexed with GW780159X to be published
1BI8	MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURES CDK6-P19INK4D INHIBITOR COMPLEX 分子名称: CYCLIN-DEPENDENT KINASE 6, CYCLIN-DEPENDENT KINASE INHIBITOR 著者 Russo, A.A, Tong, L, Lee, J.O, Jeffrey, P.D, Pavletich, N.P. 登録日 1998-06-22 公開日 1999-01-13 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature, 395, 1998
1B6C	CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF-BETA RECEPTOR IN COMPLEX WITH FKBP12 分子名称: FK506-BINDING PROTEIN, SULFATE ION, TGF-B SUPERFAMILY RECEPTOR TYPE I 著者 Huse, M, Chen, Y.-G, Massague, J, Kuriyan, J. 登録日 1999-01-13 公開日 1999-06-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12. Cell(Cambridge,Mass.), 96, 1999
1BUH	CRYSTAL STRUCTURE OF THE HUMAN CDK2 KINASE COMPLEX WITH CELL CYCLE-REGULATORY PROTEIN CKSHS1 分子名称: PROTEIN (CDK2 HUMAN), PROTEIN (CKSHS1 HUMAN) 著者 Bourne, Y, Tainer, J.A. 登録日 1998-09-03 公開日 1998-09-09 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. Cell(Cambridge,Mass.), 84, 1996
4F7L	Crystal structure of human CDK8/CYCC in complex with compound 2 (tert-butyl [3-({[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)propyl]carbamate) 分子名称: Cyclin-C, Cyclin-dependent kinase 8, tert-butyl [3-({[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)propyl]carbamate 著者 Schneider, E.V, Boettcher, J, Huber, R, Maskos, K. 登録日 2012-05-16 公開日 2013-05-01 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure-kinetic relationship study of CDK8/CycC specific compounds. Proc.Natl.Acad.Sci.USA, 110, 2013
4F70	Crystal structure of human CDK8/CYCC in complex with compound 4 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[2-(morpholin-4-yl)ethyl]urea) 分子名称: 1,2-ETHANEDIOL, 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[2-(morpholin-4-yl)ethyl]urea, Cyclin-C, ... 著者 Schneider, E.V, Boettcher, J, Huber, R, Maskos, K. 登録日 2012-05-15 公開日 2013-05-01 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure-kinetic relationship study of CDK8/CycC specific compounds. Proc.Natl.Acad.Sci.USA, 110, 2013

<152153154155156157158159160161162163164165166167>