5KKR

KSR2:MEK1 Complex Bound to the Small Molecule APS-2-79

Summary for 5KKR

Entry DOI	10.2210/pdb5kkr/pdb
Descriptor	Kinase suppressor of Ras 2, Dual specificity mitogen-activated protein kinase kinase 1, 6,7-dimethoxy-~{N}-(2-methyl-4-phenoxy-phenyl)quinazolin-4-amine (3 entities in total)
Functional Keywords	kinase suppressor of ras small molecule complex, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	80798.08
Authors	Dhawan, N.S.,Scopton, A.P.,Dar, A.C. (deposition date: 2016-06-22, release date: 2016-08-31, Last modification date: 2023-09-27)
Primary citation	Dhawan, N.S.,Scopton, A.P.,Dar, A.C. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature, 537:112-116, 2016 Cited by PubMed: 27556948 DOI: 10.1038/nature19327 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.509 Å)

Structure validation