5D9K

Rsk2 N-terminal Kinase in Complex with BI-D1870

Summary for 5D9K

• Entry DOI: 10.2210/pdb5d9k/pdb
• Related: 5D9L
• Descriptor: Ribosomal protein S6 kinase alpha-3, (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one, GLYCEROL, ... (4 entities in total)
• Functional Keywords: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P51812
• Total number of polymer chains: 2
• Total formula weight: 76928.72

Authors

Appleton, B.A. (deposition date: 2015-08-18, release date: 2015-09-02, Last modification date: 2024-03-06)

• Primary citation: Jain, R.,Mathur, M.,Lan, J.,Costales, A.,Atallah, G.,Ramurthy, S.,Subramanian, S.,Setti, L.,Feucht, P.,Warne, B.,Doyle, L.,Basham, S.,Jefferson, A.B.,Lindvall, M.,Appleton, B.A.,Shafer, C.M.; Discovery of Potent and Selective RSK Inhibitors as Biological Probes.; J.Med.Chem., 58:6766-6783, 2015; PubMed: 26270416; DOI: 10.1021/acs.jmedchem.5b00450

Experimental method

X-RAY DIFFRACTION (2.55 Å)