5CIP
 
 | | Crystal Structure of Unbound 4E10 | | 分子名称: | FAB 4E10 HEAVY CHAIN, FAB 4E10 LIGHT CHAIN | | 著者 | Caaveiro, J.M.M, Rujas, E, Nieva, J.L, Tsumoto, K. | | 登録日 | 2015-07-13 | | 公開日 | 2015-09-23 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10
J.Virol., 89, 2015
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3DGG
 | | Crystal structure of FabOX108 | | 分子名称: | FabOX108 Heavy Chain Fragment, FabOX108 Light Chain Fragment, MAGNESIUM ION | | 著者 | Ren, J, Nettleship, J.E, Owens, R.J, Oxford Protein Production Facility (OPPF) | | 登録日 | 2008-06-13 | | 公開日 | 2008-08-12 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | A pipeline for the production of antibody fragments for structural studies using transient expression in HEK 293T cells.
Protein Expr.Purif., 62, 2008
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3DIF
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4ZFF
 | | Dual-acting Fab 5A12 in complex with VEGF | | 分子名称: | Fragment antigen binding (Fab) 5A12 Heavy chain, Fragment antigen binding (Fab) 5A12 Light chain, SULFATE ION, ... | | 著者 | Harris, S.F, Wu, P. | | 登録日 | 2015-04-21 | | 公開日 | 2015-07-01 | | 最終更新日 | 2015-09-16 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration.
J.Biol.Chem., 290, 2015
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7QNY
 | | The receptor binding domain of SARS-CoV-2 spike glycoprotein in complex with COVOX-58 and COVOX-158 Fabs | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-158 heavy chain, COVOX-158 light chain, ... | | 著者 | Zhou, D, Ren, J, Stuart, D.I. | | 登録日 | 2021-12-23 | | 公開日 | 2022-01-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | | 主引用文献 | SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.
Cell, 185, 2022
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6DFH
 | | BG505 MD64 N332-GT2 SOSIP trimer in complex with germline-reverted BG18 fragment antigen binding | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | | 著者 | Ozorowski, G, Steichen, J.M, Schief, W.R, Ward, A.B. | | 登録日 | 2018-05-14 | | 公開日 | 2019-11-06 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.85 Å) | | 主引用文献 | A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses.
Science, 366, 2019
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6DFG
 | | BG505 MD39 SOSIP trimer in complex with mature BG18 fragment antigen binding | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | | 著者 | Ozorowski, G, Steichen, J.M, Schief, W.R, Ward, A.B. | | 登録日 | 2018-05-14 | | 公開日 | 2019-11-06 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (4.42 Å) | | 主引用文献 | A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses.
Science, 366, 2019
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8T0O
 | | Fab from mAb RB2AT_87 | | 分子名称: | CHLORIDE ION, RB2AT_87 Fab Heavy chain, RB2AT_87 Fab Light chain | | 著者 | Kreutzer, A.G, Malonis, R.J, Lai, J.R, Nowick, J.S. | | 登録日 | 2023-06-01 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Generation and Study of Antibodies against Two Triangular Trimers Derived from A beta.
Pept Sci (Hoboken), 116, 2024
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2R69
 | | Crystal structure of Fab 1A1D-2 complexed with E-DIII of Dengue virus at 3.8 angstrom resolution | | 分子名称: | Heavy chain of 1A1D-2, Light chain of 1A1D-2, Major envelope protein E | | 著者 | Lok, S.M, Kostyuchenko, V.K, Nybakken, G.E, Holdaway, H.A, Battisti, A.J, Sukupolvi-petty, S, Sedlak, D, Fremont, D.H, Chipman, P.R, Roehrig, J.T, Diamond, M.S, Kuhn, R.J, Rossmann, M.G. | | 登録日 | 2007-09-05 | | 公開日 | 2007-12-25 | | 最終更新日 | 2018-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins.
Nat.Struct.Mol.Biol., 15, 2008
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6U07
 | | Computational Stabilization of T Cell Receptor Constant Domains | | 分子名称: | MAGNESIUM ION, Stabilized T cell receptor constant domain (Calpha), Stabilized T cell receptor constant domain (Cbeta) | | 著者 | Froning, K, Maguire, J, Sereno, A, Huang, F, Chang, S, Weichert, K, Frommelt, A.J, Dong, J, Wu, X, Austin, H, Conner, E.M, Fitchett, J.R, Heng, A.R, Balasubramaniam, D, Hilgers, M.T, Kuhlman, B, Demarest, S.J. | | 登録日 | 2019-08-13 | | 公開日 | 2020-04-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics.
Nat Commun, 11, 2020
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6P4Y
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6P67
 | | Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha 2B8 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-IL-7R 2B8 Fab heavy chain, ... | | 著者 | Walsh, S.T.R, Kashi, L, Kohnhorst, C.L. | | 登録日 | 2019-06-03 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.
Leukemia, 34, 2020
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6P50
 | | Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha Fab 4A10 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-7 receptor subunit alpha, anti-IL-7R 4A10 Fab heavy chain, ... | | 著者 | Walsh, S.T.R, Kashi, L, Kohnhorst, C.L. | | 登録日 | 2019-05-29 | | 公開日 | 2019-09-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.
Leukemia, 34, 2020
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7XXL
 | | RBD in complex with Fab14 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab14 heavy chain, Fab14 light chain, ... | | 著者 | Lin, J.Q, Tan, Y.J.E, Wu, B, Lescar, J. | | 登録日 | 2022-05-30 | | 公開日 | 2022-09-14 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (7.3 Å) | | 主引用文献 | Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth.
Nat Commun, 13, 2022
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4ZFG
 | | Dual-specificity Fab 5A12 in complex with Angiopoietin 2 | | 分子名称: | Angiopoietin-2, CALCIUM ION, Fragment antigen binding 5A12 heavy chain, ... | | 著者 | Harris, S.F, Wu, P. | | 登録日 | 2015-04-21 | | 公開日 | 2015-07-01 | | 最終更新日 | 2015-09-16 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration.
J.Biol.Chem., 290, 2015
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4B5E
 | | Crystal Structure of an amyloid-beta binding single chain antibody PS2-8 | | 分子名称: | GLYCEROL, PS2-8, SULFATE ION | | 著者 | Beringer, D.X, Dorresteijn, B, Rutten, L, Wienk, H, el Khattabi, M, Kroon-Batenburg, L.M.J, Verrips, C.T. | | 登録日 | 2012-08-03 | | 公開日 | 2013-08-21 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.936 Å) | | 主引用文献 | Amyloid-Beta Binding Single Chain Antibody Ps2-8
To be Published
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2JMH
 | | NMR solution structure of Blo t 5, a major mite allergen from Blomia tropicalis | | 分子名称: | Mite allergen Blo t 5 | | 著者 | Naik, M.T, Chang, C, Kuo, I, Chua, K, Huang, T. | | 登録日 | 2006-11-12 | | 公開日 | 2007-11-13 | | 最終更新日 | 2023-12-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Roles of Structure and Structural Dynamics in the Antibody Recognition of the Allergen Proteins: An NMR Study on Blomia tropicalis Major Allergen
Structure, 16, 2008
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6PBW
 | | Crystal structure of Fab667 complex | | 分子名称: | Fab667 heavy chain, Fab667 light chain, GLYCEROL, ... | | 著者 | Oyen, D, Wilson, I.A. | | 登録日 | 2019-06-14 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.058 Å) | | 主引用文献 | Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein.
Plos Pathog., 16, 2020
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3KYM
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2R6P
 | | Fit of E protein and Fab 1A1D-2 into 24 angstrom resolution cryoEM map of Fab complexed with dengue 2 virus. | | 分子名称: | Heavy chain of 1A1D-2, Light chain of 1A1D-2, Major envelope protein E | | 著者 | Lok, S.M, Kostyuchenko, V.K, Holdaway, H.A, Chipman, P.R, Kuhn, R.J, Rossmann, M.G. | | 登録日 | 2007-09-06 | | 公開日 | 2007-12-25 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (24 Å) | | 主引用文献 | Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins.
Nat.Struct.Mol.Biol., 15, 2008
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2V17
 | | Structure of the complex of antibody MN423 with a fragment of tau protein | | 分子名称: | MONOCLONAL ANTIBODY FAB FRAGMENT MN423, PEPTIDE FRAGMENT | | 著者 | Sevcik, J, Skrabana, R, Csokova, N, Dvorsky, R, Novak, M. | | 登録日 | 2007-05-22 | | 公開日 | 2007-12-25 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | X-Ray Structure of the Phf Core C-Terminus: Insight Into the Folding of the Intrinsically Disordered Protein Tau in Alzheimer'S Disease.
FEBS Lett., 581, 2007
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4HLZ
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3U46
 | | CH04H/CH02L P212121 | | 分子名称: | CH02 Light chain Fab, CH04 Heavy chain Fab | | 著者 | Louder, R, Pancera, M, McLellan, J.S, Kwong, P.D. | | 登録日 | 2011-10-07 | | 公開日 | 2011-11-30 | | 最終更新日 | 2011-12-21 | | 実験手法 | X-RAY DIFFRACTION (2.906 Å) | | 主引用文献 | Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
Nature, 480, 2011
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6OBD
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1QD0
 | | CAMELID HEAVY CHAIN VARIABLE DOMAINS PROVIDE EFFICIENT COMBINING SITES TO HAPTENS | | 分子名称: | 3-HYDROXY-7-(4-{1-[2-HYDROXY-3-(2-HYDROXY-5-SULFO-PHENYLAZO)-BENZYL]-2-SULFO-ETHYLAMINO}-[1,2,5]TRIAZIN-2-YLAMINO)-2-(2-HYDROXY-5-SULFO-PHENYLAZO)-NAPTHALENE-1,8-DISULFONIC ACID, COPPER (II) ION, VHH-R2 ANTI-RR6 ANTIBODY | | 著者 | Spinelli, S, Frenken, L.G.J, Hermans, P, Verrips, T, Brown, K, Tegoni, M, Cambillau, C. | | 登録日 | 1999-07-08 | | 公開日 | 2000-07-19 | | 最終更新日 | 2018-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Camelid heavy-chain variable domains provide efficient combining sites to haptens.
Biochemistry, 39, 2000
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