6U07
Computational Stabilization of T Cell Receptor Constant Domains
Summary for 6U07
Entry DOI | 10.2210/pdb6u07/pdb |
Descriptor | Stabilized T cell receptor constant domain (Calpha), Stabilized T cell receptor constant domain (Cbeta), MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | t cell receptor, tcr constant domains, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 27096.73 |
Authors | Froning, K.,Maguire, J.,Sereno, A.,Huang, F.,Chang, S.,Weichert, K.,Frommelt, A.J.,Dong, J.,Wu, X.,Austin, H.,Conner, E.M.,Fitchett, J.R.,Heng, A.R.,Balasubramaniam, D.,Hilgers, M.T.,Kuhlman, B.,Demarest, S.J. (deposition date: 2019-08-13, release date: 2020-04-15, Last modification date: 2023-10-11) |
Primary citation | Froning, K.,Maguire, J.,Sereno, A.,Huang, F.,Chang, S.,Weichert, K.,Frommelt, A.J.,Dong, J.,Wu, X.,Austin, H.,Conner, E.M.,Fitchett, J.R.,Heng, A.R.,Balasubramaniam, D.,Hilgers, M.T.,Kuhlman, B.,Demarest, S.J. Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics. Nat Commun, 11:2330-2330, 2020 Cited by PubMed: 32393818DOI: 10.1038/s41467-020-16231-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
Download full validation report