6U07

Computational Stabilization of T Cell Receptor Constant Domains

Summary for 6U07

• Entry DOI: 10.2210/pdb6u07/pdb
• Descriptor: Stabilized T cell receptor constant domain (Calpha), Stabilized T cell receptor constant domain (Cbeta), MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: t cell receptor, tcr constant domains, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 27096.73

Authors

Froning, K.,Maguire, J.,Sereno, A.,Huang, F.,Chang, S.,Weichert, K.,Frommelt, A.J.,Dong, J.,Wu, X.,Austin, H.,Conner, E.M.,Fitchett, J.R.,Heng, A.R.,Balasubramaniam, D.,Hilgers, M.T.,Kuhlman, B.,Demarest, S.J. (deposition date: 2019-08-13, release date: 2020-04-15, Last modification date: 2023-10-11)

• Primary citation: Froning, K.,Maguire, J.,Sereno, A.,Huang, F.,Chang, S.,Weichert, K.,Frommelt, A.J.,Dong, J.,Wu, X.,Austin, H.,Conner, E.M.,Fitchett, J.R.,Heng, A.R.,Balasubramaniam, D.,Hilgers, M.T.,Kuhlman, B.,Demarest, S.J.; Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics.; Nat Commun, 11:2330-2330, 2020; PubMed: 32393818; DOI: 10.1038/s41467-020-16231-7

Experimental method

X-RAY DIFFRACTION (1.76 Å)