2R69

Crystal structure of Fab 1A1D-2 complexed with E-DIII of Dengue virus at 3.8 angstrom resolution

Summary for 2R69

Entry DOI	10.2210/pdb2r69/pdb
Descriptor	Major envelope protein E, Heavy chain of 1A1D-2, Light chain of 1A1D-2 (3 entities in total)
Functional Keywords	fab-antigen complex, capsid protein, cleavage on pair of basic residues, core protein, envelope protein, glycoprotein, membrane, transmembrane, virion, viral protein-immune system complex, viral protein/immune system
Biological source	Dengue virus 2 Thailand/16681/84 More
Cellular location	Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted : P18356
Total number of polymer chains	3
Total formula weight	57272.09
Authors	Lok, S.M.,Kostyuchenko, V.K.,Nybakken, G.E.,Holdaway, H.A.,Battisti, A.J.,Sukupolvi-petty, S.,Sedlak, D.,Fremont, D.H.,Chipman, P.R.,Roehrig, J.T.,Diamond, M.S.,Kuhn, R.J.,Rossmann, M.G. (deposition date: 2007-09-05, release date: 2007-12-25, Last modification date: 2018-01-24)
Primary citation	Lok, S.M.,Kostyuchenko, V.,Nybakken, G.E.,Holdaway, H.A.,Battisti, A.J.,Sukupolvi-Petty, S.,Sedlak, D.,Fremont, D.H.,Chipman, P.R.,Roehrig, J.T.,Diamond, M.S.,Kuhn, R.J.,Rossmann, M.G. Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins. Nat.Struct.Mol.Biol., 15:312-317, 2008 Cited by PubMed: 18264114 DOI: 10.1038/nsmb.1382 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.8 Å)

Structure validation