Crystal structure of Li33 IgG2 di-Fab

Summary for 3KYM

DescriptorLight Chain Li33 IgG2, Heavy Chain Li33 IgG2 (2 entities in total)
Functional Keywordsigg2 monoclonal anti-lingo, immune system
Biological sourceHomo sapiens
Total number of polymer chains16
Total molecular weight383291.56
Silvian, L.F.,Pepinsky, R.B.,Walus, L. (deposition date: 2009-12-06, release date: 2010-03-16, Last modification date: 2011-07-13)
Primary citation
Pepinsky, R.B.,Silvian, L.,Berkowitz, S.A.,Farrington, G.,Lugovskoy, A.,Walus, L.,Eldredge, J.,Capili, A.,Mi, S.,Graff, C.,Garber, E.
Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis.
Protein Sci., 19:954-966, 2010
PubMed: 20198683 (PDB entries with the same primary citation)
DOI: 10.1002/pro.372
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.332215.3%16.1%4.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution