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8FY8
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5-MeO-DMT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
分子名称: 2-(5-methoxy-1H-indol-3-yl)-N,N-dimethylethan-1-amine, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D.
登録日2023-01-25
公開日2024-05-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.79 Å)
主引用文献Structural pharmacology and therapeutic potential of 5-methoxytryptamines.
Nature, 2024
8FX5
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Human M4 muscarinic acetylcholine receptor complex with Gi1 and xanomeline
分子名称: Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Vuckovic, Z, Mobbs, J.I, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M.
登録日2023-01-23
公開日2023-09-13
実験手法ELECTRON MICROSCOPY (2.45 Å)
主引用文献Xanomeline displays concomitant orthosteric and allosteric binding modes at the M 4 mAChR.
Nat Commun, 14, 2023
8FU6
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GCGR-Gs complex in the presence of RAMP2
分子名称: Glucagon derivative ZP3780, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Krishna Kumar, K, O'Brien, E.S, Wang, H, Montabana, E, Kobilka, B.K.
登録日2023-01-16
公開日2023-04-12
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Negative allosteric modulation of the glucagon receptor by RAMP2.
Cell, 186, 2023
8FN1
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CryoEM structure of Go-coupled NTSR1
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ...
著者Krumm, B.E, DiBerto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L.
登録日2022-12-26
公開日2023-03-29
最終更新日2023-04-19
実験手法ELECTRON MICROSCOPY (2.88 Å)
主引用文献Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.
Biochemistry, 62, 2023
8FN0
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CryoEM structure of Go-coupled NTSR1 with a biased allosteric modulator
分子名称: 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Krumm, B.E, DiBerto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L.
登録日2022-12-26
公開日2023-03-29
最終更新日2023-04-19
実験手法ELECTRON MICROSCOPY (2.89 Å)
主引用文献Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.
Biochemistry, 62, 2023
8FMZ
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Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, MiniGq, ...
著者Krumm, B.E, Diberto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L.
登録日2022-12-26
公開日2023-03-29
最終更新日2023-04-19
実験手法ELECTRON MICROSCOPY (2.59 Å)
主引用文献Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.
Biochemistry, 62, 2023
8FLU
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Human PTH1R in complex with LA-PTH and Gs
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
登録日2022-12-22
公開日2023-04-26
最終更新日2023-06-14
実験手法ELECTRON MICROSCOPY (2.76 Å)
主引用文献Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FLT
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Human PTH1R in complex with M-PTH(1-14) and Gs
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
登録日2022-12-22
公開日2023-04-26
最終更新日2023-06-14
実験手法ELECTRON MICROSCOPY (3.03 Å)
主引用文献Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FLS
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Human PTH1R in complex with Abaloparatide and Gs
分子名称: Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
登録日2022-12-22
公開日2023-04-26
最終更新日2023-06-14
実験手法ELECTRON MICROSCOPY (3.09 Å)
主引用文献Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FLR
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Human PTH1R in complex with PTHrP and Gs
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
登録日2022-12-22
公開日2023-04-26
最終更新日2023-06-14
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FLQ
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Human PTH1R in complex with PTH(1-34) and Gs
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
登録日2022-12-22
公開日2023-04-26
最終更新日2023-06-14
実験手法ELECTRON MICROSCOPY (2.55 Å)
主引用文献Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FEG
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CryoEM structure of Kappa Opioid Receptor bound to a semi-peptide and Gi1
分子名称: ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Fay, J.F, Che, T.
登録日2022-12-06
公開日2023-12-06
最終更新日2024-01-17
実験手法ELECTRON MICROSCOPY (2.54 Å)
主引用文献Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor.
Nat Commun, 14, 2023
8F7X
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Gi bound nociceptin receptor in complex with nociceptin peptide
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E.
登録日2022-11-20
公開日2022-12-14
最終更新日2023-02-01
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Structures of the entire human opioid receptor family.
Cell, 186, 2023
8F7W
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Gi bound kappa-opioid receptor in complex with dynorphin
分子名称: CHOLESTEROL, Dynorphin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E.
登録日2022-11-20
公開日2022-12-14
最終更新日2023-02-01
実験手法ELECTRON MICROSCOPY (3.19 Å)
主引用文献Structures of the entire human opioid receptor family.
Cell, 186, 2023
8F7S
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Gi bound delta-opioid receptor in complex with deltorphin
分子名称: CHOLESTEROL, Delta-type opioid receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E.
登録日2022-11-20
公開日2022-12-14
最終更新日2023-02-01
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structures of the entire human opioid receptor family.
Cell, 186, 2023
8F7R
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Gi bound mu-opioid receptor in complex with endomorphin
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E.
登録日2022-11-20
公開日2022-12-14
最終更新日2023-02-01
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Structures of the entire human opioid receptor family.
Cell, 186, 2023
8F7Q
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Gi bound mu-opioid receptor in complex with beta-endorphin
分子名称: Beta-endorphin, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E.
登録日2022-11-20
公開日2022-12-14
最終更新日2023-02-01
実験手法ELECTRON MICROSCOPY (3.22 Å)
主引用文献Structures of the entire human opioid receptor family.
Cell, 186, 2023
8F76
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BU of 8f76 by Molmil
Human olfactory receptor OR51E2 bound to propionate in complex with miniGs399
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Billesboelle, C.B, Manglik, A.
登録日2022-11-18
公開日2023-03-22
最終更新日2023-04-05
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis of odorant recognition by a human odorant receptor.
Nature, 615, 2023
8F2B
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Amylin 3 Receptor in complex with Gs and Pramlintide analogue peptide San45
分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
著者Cao, J, Sexton, P.M, Wootten, D.L, Belousoff, M.J.
登録日2022-11-07
公開日2023-08-02
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2 Å)
主引用文献Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
8F2A
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Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385 (Cluster 5 conformation)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Cao, J, Sexton, P.M, Wootten, D.L, Radostin, D.
登録日2022-11-07
公開日2023-08-02
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.2 Å)
主引用文献Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
8F0K
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Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385
分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
著者Cao, J, Sexton, P.M, Wootten, D.L.
登録日2022-11-03
公開日2023-08-02
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (1.9 Å)
主引用文献Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
8F0J
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BU of 8f0j by Molmil
Calcitonin Receptor in complex with Gs and Pramlintide analogue peptide San45
分子名称: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
著者Cao, J, Sexton, P.M, Wootten, D.L, Belousoff, M.J.
登録日2022-11-03
公開日2023-08-02
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (2 Å)
主引用文献Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
8EMX
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Phospholipase C beta 3 (PLCb3) in complex with Gbg on lipid nanodiscs
分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Falzone, M.E, MacKinnon, R.
登録日2022-09-28
公開日2023-05-24
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EMW
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Phospholipase C beta 3 (PLCb3) in complex with Gbg on liposomes
分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Falzone, M.E, MacKinnon, R.
登録日2022-09-28
公開日2023-05-24
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献G beta gamma activates PIP2 hydrolysis by recruiting and orienting PLC beta on the membrane surface.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EJK
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Structure of FFAR1-Gq complex bound to TAK-875 in a lipid nanodisc
分子名称: A modified Guanine nucleotide-binding protein G(q) subunit alpha, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M.
登録日2022-09-17
公開日2023-05-24
最終更新日2023-05-31
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Molecular mechanism of fatty acid activation of FFAR1.
Proc.Natl.Acad.Sci.USA, 120, 2023

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件を2024-06-12に公開中

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