6DPU
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![BU of 6dpu by Molmil](/molmil-images/mine/6dpu) | Undecorated GMPCPP microtubule | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | 著者 | Zhang, R, Nogales, E. | 登録日 | 2018-06-09 | 公開日 | 2018-07-04 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Separating the effects of nucleotide and EB binding on microtubule structure. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6LSN
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![BU of 6lsn by Molmil](/molmil-images/mine/6lsn) | Crystal structure of tubulin-inhibitor complex | 分子名称: | 2-(1-methylindol-5-yl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Gang, L, Wang, Y.X, Cheng, J.J. | 登録日 | 2020-01-17 | 公開日 | 2021-01-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.445 Å) | 主引用文献 | Design, Synthesis, and Bioevaluation of Pyrazolo[1,5-a]Pyrimidine Derivatives as Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site with Potent Anticancer Activities To Be Published
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6FKL
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![BU of 6fkl by Molmil](/molmil-images/mine/6fkl) | Tubulin-TUB015 complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-{1-[(2-Methoxyphenyl)amino]ethylidene}-5-phenyl-1,3-cyclohexanedione, CALCIUM ION, ... | 著者 | Prota, A.E, Steinmetz, M.O, Priego, E.-M. | 登録日 | 2018-01-24 | 公開日 | 2018-03-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.098 Å) | 主引用文献 | High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design. Sci Rep, 8, 2018
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6FKJ
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![BU of 6fkj by Molmil](/molmil-images/mine/6fkj) | Tubulin-TUB075 complex | 分子名称: | (5~{S})-2-[(~{E})-~{N}-(2-ethoxyphenyl)-~{C}-methyl-carbonimidoyl]-3-oxidanyl-5-phenyl-cyclohex-2-en-1-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Prota, A.E, Steinmetz, M.O, Priego, E.-M. | 登録日 | 2018-01-24 | 公開日 | 2018-03-21 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.148 Å) | 主引用文献 | High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design. Sci Rep, 8, 2018
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6MZG
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![BU of 6mzg by Molmil](/molmil-images/mine/6mzg) | |
6MZE
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![BU of 6mze by Molmil](/molmil-images/mine/6mze) | |
6E88
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![BU of 6e88 by Molmil](/molmil-images/mine/6e88) | Cryo-EM structure of C. elegans GDP-microtubule | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Tubulin alpha-2 chain, ... | 著者 | Chaaban, S, Jariwala, S, Chieh-Ting, H, Redemann, S, Kollman, J, Muller-Reichert, T, Sept, D, Bui, K.H, Brouhard, G.J. | 登録日 | 2018-07-27 | 公開日 | 2018-10-10 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | The Structure and Dynamics of C. elegans Tubulin Reveals the Mechanistic Basis of Microtubule Growth. Dev. Cell, 47, 2018
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6MZF
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6F7C
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![BU of 6f7c by Molmil](/molmil-images/mine/6f7c) | TUBULIN-Compound 12 complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,4,5-trimethoxy-~{N}-[(~{E})-naphthalen-1-ylmethylideneamino]benzamide, CALCIUM ION, ... | 著者 | Muehlethaler, T, Prota, A.E, Steinmetz, M.O. | 登録日 | 2017-12-08 | 公開日 | 2018-12-19 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | 主引用文献 | Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia. Iscience, 21, 2019
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6MLR
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![BU of 6mlr by Molmil](/molmil-images/mine/6mlr) | Cryo-EM structure of microtubule-bound Kif7 in the AMPPNP state | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF7, ... | 著者 | Mani, N, Jiang, S, Wilson-Kubalek, E.M, Ku, P, Milligan, R.A, Subramanian, R. | 登録日 | 2018-09-27 | 公開日 | 2019-05-01 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Interplay between the Kinesin and Tubulin Mechanochemical Cycles Underlies Microtubule Tip Tracking by the Non-motile Ciliary Kinesin Kif7. Dev.Cell, 49, 2019
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6N47
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![BU of 6n47 by Molmil](/molmil-images/mine/6n47) | The structure of SB-2-204-tubulin complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-chloropyrido[3,2-d]pyrimidin-4-yl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, CALCIUM ION, ... | 著者 | Arnst, K, Banerjee, S, Wang, Y, Li, W, Miller, D, Li, W. | 登録日 | 2018-11-17 | 公開日 | 2019-11-13 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | X-ray Crystal Structure Guided Discovery and Antitumor Efficacy of Dihydroquinoxalinone as Potent Tubulin Polymerization Inhibitors. Acs Chem.Biol., 14, 2019
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6MLQ
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![BU of 6mlq by Molmil](/molmil-images/mine/6mlq) | Cryo-EM structure of microtubule-bound Kif7 in the ADP state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Mani, N, Jiang, S, Wilson-Kubalek, E.M, Ku, P, Milligan, R.A, Subramanian, R. | 登録日 | 2018-09-27 | 公開日 | 2019-05-01 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Interplay between the Kinesin and Tubulin Mechanochemical Cycles Underlies Microtubule Tip Tracking by the Non-motile Ciliary Kinesin Kif7. Dev.Cell, 49, 2019
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6NNG
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![BU of 6nng by Molmil](/molmil-images/mine/6nng) | Tubulin-RB3_SLD-TTL in complex with compound DJ95 | 分子名称: | 2-(1H-indol-6-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Kumar, G, Wang, Y, Li, W, White, S.W. | 登録日 | 2019-01-15 | 公開日 | 2019-07-10 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (2.397 Å) | 主引用文献 | Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy. Mol.Pharmacol., 96, 2019
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6LSM
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![BU of 6lsm by Molmil](/molmil-images/mine/6lsm) | Tubulin Polymerization Inhibitors | 分子名称: | 2-(4-methylphenyl)-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Gang, L, Wang, Y.X, Chen, J.J. | 登録日 | 2020-01-17 | 公開日 | 2021-01-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.751 Å) | 主引用文献 | Design, Synthesis, and Bioevaluation of Pyrazolo[1,5-a]Pyrimidine Derivatives as Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site with Potent Anticancer Activities To Be Published
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6LL6
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![BU of 6ll6 by Molmil](/molmil-images/mine/6ll6) | Crsyal structure of EcFtsZ (residues 11-316) | 分子名称: | Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE | 著者 | Yoshizawa, T, Fujita, J, Terakada, H, Ozawa, M, Kuroda, N, Tanaka, S, Uehara, R, Matsumura, H. | 登録日 | 2019-12-21 | 公開日 | 2020-02-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structures of the cell-division protein FtsZ from Klebsiella pneumoniae and Escherichia coli. Acta Crystallogr.,Sect.F, 76, 2020
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8SNB
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![BU of 8snb by Molmil](/molmil-images/mine/8snb) | |
8SH7
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![BU of 8sh7 by Molmil](/molmil-images/mine/8sh7) | |
8TO0
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![BU of 8to0 by Molmil](/molmil-images/mine/8to0) | 48-nm repeating structure of doublets from mouse sperm flagella | 分子名称: | Cilia- and flagella- associated protein 210, Cilia- and flagella-associated protein 107, Cilia- and flagella-associated protein 141, ... | 著者 | Chen, Z, Shiozak, M, Hass, K.M, Skinner, W, Zhao, S, Guo, C, Polacco, B.J, Yu, Z, Krogan, N.J, Kaake, R.M, Vale, R.D, Agard, D.A. | 登録日 | 2023-08-02 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (7.7 Å) | 主引用文献 | De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking. Cell, 186, 2023
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8T42
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![BU of 8t42 by Molmil](/molmil-images/mine/8t42) | Model of TTLL6 MTBH1-2 bound to microtubule | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | 著者 | Mahalingan, K.K, Grotjahn, D, Li, Y, Lander, G.C, Zehr, E.A, Roll-Mecak, A. | 登録日 | 2023-06-08 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis for alpha-tubulin-specific and modification state-dependent glutamylation. Nat.Chem.Biol., 2024
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8VA2
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![BU of 8va2 by Molmil](/molmil-images/mine/8va2) | |
8RC1
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![BU of 8rc1 by Molmil](/molmil-images/mine/8rc1) | |
8RIW
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![BU of 8riw by Molmil](/molmil-images/mine/8riw) | T2R-TTL-1-L01 complex | 分子名称: | (2-methyl-1~{H}-indol-5-yl) 3,4,5-trimethoxybenzenesulfonate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Prota, A.E.P, Boiarska, Z, Homer, J.A, Steinmetz, M.O, Moses, J.E. | 登録日 | 2023-12-19 | 公開日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Modular synthesis of functional libraries by accelerated SuFEx click chemistry. Chem Sci, 15, 2024
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8RIV
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![BU of 8riv by Molmil](/molmil-images/mine/8riv) | T2R-TTL-1-K08 complex | 分子名称: | (4-fluoranyl-2-methyl-1~{H}-indol-5-yl) 3,4,5-trimethoxybenzenesulfonate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Boiarska, Z, Homer, J.A, Steinmetz, M.O, Moses, J.E, Prota, A.E.P. | 登録日 | 2023-12-19 | 公開日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | Modular synthesis of functional libraries by accelerated SuFEx click chemistry. Chem Sci, 15, 2024
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8UTT
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![BU of 8utt by Molmil](/molmil-images/mine/8utt) | KIF1A[1-393] P305L mutant AMP-PNP bound two-heads-bound state in complex with a microtubule | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF1A, ... | 著者 | Benoit, M.P.M.H, Rao, L, Asenjo, A.B, Gennerich, A, Sosa, H. | 登録日 | 2023-10-31 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Cryo-EM of human KIF1A reveals its mechanism of motility and the effect of its pathogenic variant P305L To Be Published
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8UTO
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![BU of 8uto by Molmil](/molmil-images/mine/8uto) | KIF1A[1-393] AMP-PNP bound two-heads-bound state in complex with a microtubule - class T2L1 | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF1A, ... | 著者 | Benoit, M.P.M.H, Rao, L, Asenjo, A.B, Gennerich, A, Sosa, H. | 登録日 | 2023-10-31 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM of human KIF1A reveals its mechanism of motility and the effect of its pathogenic variant P305L To Be Published
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