6MLR

Cryo-EM structure of microtubule-bound Kif7 in the AMPPNP state

Summary for 6MLR

Entry DOI	10.2210/pdb6mlr/pdb
EMDB information	9141
Descriptor	Tubulin alpha-1A chain, Tubulin beta chain, Kinesin-like protein KIF7, ... (7 entities in total)
Functional Keywords	microtubule tip-tracking, primary cilium, hedgehog signaling, motor protein, motor protein-inhibitor complex, motor protein/inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	146018.78
Authors	Mani, N.,Jiang, S.,Wilson-Kubalek, E.M.,Ku, P.,Milligan, R.A.,Subramanian, R. (deposition date: 2018-09-27, release date: 2019-05-01, Last modification date: 2024-03-13)
Primary citation	Jiang, S.,Mani, N.,Wilson-Kubalek, E.M.,Ku, P.I.,Milligan, R.A.,Subramanian, R. Interplay between the Kinesin and Tubulin Mechanochemical Cycles Underlies Microtubule Tip Tracking by the Non-motile Ciliary Kinesin Kif7. Dev.Cell, 49:711-730.e8, 2019 Cited by PubMed: 31031197 DOI: 10.1016/j.devcel.2019.04.001 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.2 Å)

Structure validation