6N47

The structure of SB-2-204-tubulin complex

Summary for 6N47

Entry DOI	10.2210/pdb6n47/pdb
Descriptor	Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-chloropyrido[3,2-d]pyrimidin-4-yl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, ... (13 entities in total)
Functional Keywords	tubulin, complex, inhibitor, structural protein
Biological source	Sus scrofa (Pig) More
Total number of polymer chains	6
Total formula weight	265189.89
Authors	Arnst, K.,Banerjee, S.,Wang, Y.,Li, W.,Miller, D.,Li, W. (deposition date: 2018-11-17, release date: 2019-11-13, Last modification date: 2024-03-13)
Primary citation	Arnst, K.E.,Banerjee, S.,Wang, Y.,Chen, H.,Li, Y.,Yang, L.,Li, W.,Miller, D.D.,Li, W. X-ray Crystal Structure Guided Discovery and Antitumor Efficacy of Dihydroquinoxalinone as Potent Tubulin Polymerization Inhibitors. Acs Chem.Biol., 14:2810-2821, 2019 Cited by PubMed: 31714738 DOI: 10.1021/acschembio.9b00696 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation