8DMB
| Structure of Desulfovirgula thermocuniculi IsrB (DtIsrB) in complex with omega RNA and target DNA | 分子名称: | MAGNESIUM ION, Ubiquitin-like protein SMT3,IsrB protein,monomeric superfolder Green Fluorescent Protein, non-target DNA, ... | 著者 | Seiichi, H, Kappel, K, Zhang, F. | 登録日 | 2022-07-08 | 公開日 | 2022-10-19 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of the OMEGA nickase IsrB in complex with omega RNA and target DNA. Nature, 610, 2022
|
|
7Q34
| Crystal structure of the multidrug binding transcriptional regulator LmrR in complex squaraine dye | 分子名称: | 2,4-bis[(E)-(1-ethyl-3,3-dimethyl-indol-2-ylidene)methyl]cyclobutane-1,3-dione, Helix-turn-helix transcriptional regulator, NICKEL (II) ION | 著者 | Liutkus, M, Mejias, S.H, Barolo, C, Cortajarena, A.L. | 登録日 | 2021-10-26 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Designing Artificial Fluorescent Proteins: Squaraine-LmrR Biophosphors for High Performance Deep-Red Biohybrid Light-Emitting Diodes Adv Funct Mater, 32, 2022
|
|
7Q4A
| Toxoplasma gondii PRP4K kinase domain (L715F) bound to altiratinib | 分子名称: | Altiratinib, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Swale, C, Bellini, V, Bowler, M. | 登録日 | 2021-10-29 | 公開日 | 2022-08-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase. Sci Transl Med, 14, 2022
|
|
7PX1
| Conotoxin from Conus mucronatus | 分子名称: | CADMIUM ION, Conus mucronatus, IODIDE ION | 著者 | Mueller, E, Hackney, C.M, Ellgaard, L, Morth, J.P. | 登録日 | 2021-10-07 | 公開日 | 2022-11-02 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2.3. Plos Biol., 21, 2023
|
|
7PX2
| Conotoxin Mu8.1 from Conus mucronatus | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Conotoxin Mu8.1 | 著者 | Mueller, E, Hackney, C, Ellgaard, L, Morth, J.P. | 登録日 | 2021-10-07 | 公開日 | 2022-11-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2.3. Plos Biol., 21, 2023
|
|
7SII
| Human STING bound to both cGAMP and 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide (Compound 53) | 分子名称: | 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, Stimulator of interferon genes protein, cGAMP | 著者 | Lu, D, Shang, G, Jie, L, Lu, Y, Bai, X.C, Zhang, X. | 登録日 | 2021-10-14 | 公開日 | 2022-02-02 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Activation of STING by targeting a pocket in the transmembrane domain. Nature, 604, 2022
|
|
7QF1
| Crystal structure of the SARS-CoV-2 RBD in complex with the human antibody CV2.6264 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CV2.6264 heavy chain, CV2.6264 light chain, ... | 著者 | Fernandez, I, Pederzoli, R, Rey, F.A. | 登録日 | 2021-12-03 | 公開日 | 2022-05-18 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2. J.Exp.Med., 219, 2022
|
|
7QF0
| Crystal structure of the SARS-CoV-2 RBD in complex with the human antibody CV2.2325 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, CV2.2325 heavy chain, ... | 著者 | Fernandez, I, Pederzoli, R, Rey, F.A. | 登録日 | 2021-12-03 | 公開日 | 2022-05-18 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2. J.Exp.Med., 219, 2022
|
|
7QEZ
| |
7QCE
| Crystal structure of an atypical PHD finger of VIN3 | 分子名称: | DI(HYDROXYETHYL)ETHER, VIN3 (Protein VERNALIZATION INSENSITIVE 3), ZINC ION | 著者 | Franco-Echevarria, E, Fiedler, M, Dean, C, Bienz, M. | 登録日 | 2021-11-23 | 公開日 | 2022-11-16 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Plant vernalization proteins contain unusual PHD superdomains without histone H3 binding activity. J.Biol.Chem., 298, 2022
|
|
8BJT
| Structure of human PLK1 in complex with 2-Allyl-1-[6-(1-hydroxy-1-methyl-ethyl)-pyridin-2-yl]-6-[4-(4-methyl-piperazin-1-yl)-phenylamino]-1,2-dihydro-pyrazolo[3,4-d]pyrimidin-3-one | 分子名称: | 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one, ACETATE ION, Serine/threonine-protein kinase PLK1, ... | 著者 | Musil, D, Liu-Bujalski, L. | 登録日 | 2022-11-06 | 公開日 | 2023-04-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.188 Å) | 主引用文献 | Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression. Acs Med.Chem.Lett., 14, 2023
|
|
8BJU
| |
3OQ9
| Structure of the FAS/FADD death domain assembly | 分子名称: | Protein FADD, Tumor necrosis factor receptor superfamily member 6 | 著者 | Kabaleeswaran, V, Wu, H. | 登録日 | 2010-09-02 | 公開日 | 2010-10-13 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (6.8 Å) | 主引用文献 | The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat.Struct.Mol.Biol., 17, 2010
|
|
1F3B
| CRYSTAL STRUCTURE OF MGSTA1-1 IN COMPLEX WITH GLUTATHIONE CONJUGATE OF BENZO[A]PYRENE EPOXIDE | 分子名称: | 2-AMINO-4-[1-(CARBOXYMETHYL-CARBAMOYL)-2-(9-HYDROXY-7,8-DIOXO-7,8,9,10-TETRAHYDRO-BENZO[DEF]CHRYSEN-10-YLSULFANYL)-ETHYLCARBAMOYL]-BUTYRIC ACID, GLUTATHIONE S-TRANSFERASE YA CHAIN | 著者 | Gu, Y, Singh, S.V, Ji, X. | 登録日 | 2000-06-01 | 公開日 | 2000-10-18 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Residue R216 and catalytic efficiency of a murine class alpha glutathione S-transferase toward benzo[a]pyrene 7(R),8(S)-diol 9(S), 10(R)-epoxide. Biochemistry, 39, 2000
|
|
1F3A
| CRYSTAL STRUCTURE OF MGSTA1-1 IN COMPLEX WITH GSH | 分子名称: | GLUTATHIONE, GLUTATHIONE S-TRANSFERASE YA CHAIN | 著者 | Gu, Y, Singh, S.V, Ji, X. | 登録日 | 2000-06-01 | 公開日 | 2000-10-18 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Residue R216 and catalytic efficiency of a murine class alpha glutathione S-transferase toward benzo[a]pyrene 7(R),8(S)-diol 9(S), 10(R)-epoxide. Biochemistry, 39, 2000
|
|
1M4U
| Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted antagonist Noggin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bone Morphogenetic Protein-7, Noggin | 著者 | Groppe, J, Greenwald, J, Wiater, E, Rodriguez-Leon, J, Economides, A.N, Kwiatkowski, W, Affolter, M, Vale, W.W, Izpisua-Belmonte, J.C, Choe, S. | 登録日 | 2002-07-03 | 公開日 | 2002-12-18 | 最終更新日 | 2022-12-21 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Structural Basis of BMP Signalling Inhibition by the Cystine Knot Protein Noggin Nature, 420, 2002
|
|
5UAE
| Crystal structure of the coiled-coil domain from Listeria Innocua Phage Integrase (Trigonal Form) | 分子名称: | CITRATE ANION, Putative integrase | 著者 | Gupta, K, Sharp, R, Yuan, J.B, Van Duyne, G.D. | 登録日 | 2016-12-19 | 公開日 | 2017-05-24 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Coiled-coil interactions mediate serine integrase directionality. Nucleic Acids Res., 45, 2017
|
|
5UDO
| |
6BWV
| |
5U96
| |
4TKY
| |
1GLF
| CRYSTAL STRUCTURES OF ESCHERICHIA COLI GLYCEROL KINASE AND THE MUTANT A65T IN AN INACTIVE TETRAMER: CONFORMATIONAL CHANGES AND IMPLICATIONS FOR ALLOSTERIC REGULATION | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, PHOSPHATE ION, ... | 著者 | Feese, M.D, Faber, H.R, Bystrom, C.E, Pettigrew, D.W, Remington, S.J. | 登録日 | 1998-08-30 | 公開日 | 1998-10-16 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Glycerol kinase from Escherichia coli and an Ala65-->Thr mutant: the crystal structures reveal conformational changes with implications for allosteric regulation. Structure, 6, 1998
|
|
7BKP
| CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Interferon-induced helicase C domain-containing protein 1, MAGNESIUM ION, ... | 著者 | Singh, R, Herrero del Valle, A, Yu, Q, Modis, Y. | 登録日 | 2021-01-16 | 公開日 | 2021-11-17 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA. Nat Commun, 12, 2021
|
|
6NT9
| Cryo-EM structure of the complex between human TBK1 and chicken STING | 分子名称: | Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein | 著者 | Shang, G, Zhang, C, Chen, Z.J, Bai, X, Zhang, X. | 登録日 | 2019-01-28 | 公開日 | 2019-03-06 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis of STING binding with and phosphorylation by TBK1. Nature, 567, 2019
|
|
1LDM
| |