8BJU

HUMAN WEE1 KINASE IN COMPLEX WITH INHIBITOR 1-[6-(1-Hydroxy-1-methyl-ethyl)-pyridin-2-yl]-2-(2-methoxy-phenyl)-6-[4-(4-methyl-piperazin-1-yl)-phenylamino]-1,2-dihydro-pyrazolo[3,4-d]pyrimidin-3-one

Summary for 8BJU

Entry DOI	10.2210/pdb8bju/pdb
Descriptor	Wee1-like protein kinase, 2-(2-methoxyphenyl)-6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1-[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]pyrazolo[3,4-d]pyrimidin-3-one (3 entities in total)
Functional Keywords	wee1, kinase, protein-inhibitor complex, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	32735.29
Authors	Musil, D.,Lan, R. (deposition date: 2022-11-06, release date: 2023-05-31, Last modification date: 2024-02-07)
Primary citation	Guler, S.,DiPoto, M.C.,Crespo, A.,Caldwell, R.,Doerfel, B.,Grossmann, N.,Ho, K.,Huck, B.,Jones, C.C.,Lan, R.,Musil, D.,Potnick, J.,Schilke, H.,Sherer, B.,Simon, S.,Sirrenberg, C.,Zhang, Z.,Liu-Bujalski, L. Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression. Acs Med.Chem.Lett., 14:566-576, 2023 Cited by PubMed: 37197456 DOI: 10.1021/acsmedchemlett.2c00481 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation