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1M4U

Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted antagonist Noggin

Summary for 1M4U
Entry DOI10.2210/pdb1m4u/pdb
Related1BMP 1ES7 3BMP
DescriptorBone Morphogenetic Protein-7, Noggin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywordsnoggin, bmp antagonist, bmp-7, bone morphogenetic protein, cystine knot, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: P18075 Q13253
Total number of polymer chains2
Total formula weight39336.98
Authors
Groppe, J.,Greenwald, J.,Wiater, E.,Rodriguez-Leon, J.,Economides, A.N.,Kwiatkowski, W.,Affolter, M.,Vale, W.W.,Izpisua-Belmonte, J.C.,Choe, S. (deposition date: 2002-07-03, release date: 2002-12-18, Last modification date: 2022-12-21)
Primary citationGroppe, J.,Greenwald, J.,Wiater, E.,Rodriguez-Leon, J.,Economides, A.N.,Kwiatkowski, W.,Affolter, M.,Vale, W.W.,Izpisua-Belmonte, J.C.,Choe, S.
Structural Basis of BMP Signalling Inhibition by the Cystine Knot Protein Noggin
Nature, 420:636-642, 2002
Cited by
PubMed: 12478285
DOI: 10.1038/nature01245
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.42 Å)
Structure validation

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