1M4U

Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted antagonist Noggin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0001501	biological_process	skeletal system development
A	0001649	biological_process	osteoblast differentiation
A	0001655	biological_process	urogenital system development
A	0001657	biological_process	ureteric bud development
A	0001701	biological_process	in utero embryonic development
A	0001706	biological_process	endoderm formation
A	0001707	biological_process	mesoderm formation
A	0001837	biological_process	epithelial to mesenchymal transition
A	0001839	biological_process	neural plate morphogenesis
A	0001843	biological_process	neural tube closure
A	0003149	biological_process	membranous septum morphogenesis
A	0003151	biological_process	outflow tract morphogenesis
A	0003223	biological_process	ventricular compact myocardium morphogenesis
A	0003272	biological_process	endocardial cushion formation
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0007224	biological_process	smoothened signaling pathway
A	0007389	biological_process	pattern specification process
A	0007399	biological_process	nervous system development
A	0007411	biological_process	axon guidance
A	0007417	biological_process	central nervous system development
A	0007420	biological_process	brain development
A	0007492	biological_process	endoderm development
A	0008045	biological_process	motor neuron axon guidance
A	0008283	biological_process	cell population proliferation
A	0008542	biological_process	visual learning
A	0008543	biological_process	fibroblast growth factor receptor signaling pathway
A	0009953	biological_process	dorsal/ventral pattern formation
A	0010628	biological_process	positive regulation of gene expression
A	0010629	biological_process	negative regulation of gene expression
A	0019955	molecular_function	cytokine binding
A	0021510	biological_process	spinal cord development
A	0021533	biological_process	cell differentiation in hindbrain
A	0021915	biological_process	neural tube development
A	0021983	biological_process	pituitary gland development
A	0021999	biological_process	neural plate anterior/posterior regionalization
A	0030154	biological_process	cell differentiation
A	0030336	biological_process	negative regulation of cell migration
A	0030509	biological_process	BMP signaling pathway
A	0030510	biological_process	regulation of BMP signaling pathway
A	0030514	biological_process	negative regulation of BMP signaling pathway
A	0030900	biological_process	forebrain development
A	0035019	biological_process	somatic stem cell population maintenance
A	0035640	biological_process	exploration behavior
A	0038092	biological_process	nodal signaling pathway
A	0040036	biological_process	regulation of fibroblast growth factor receptor signaling pathway
A	0042060	biological_process	wound healing
A	0042474	biological_process	middle ear morphogenesis
A	0042733	biological_process	embryonic digit morphogenesis
A	0042803	molecular_function	protein homodimerization activity
A	0045596	biological_process	negative regulation of cell differentiation
A	0045668	biological_process	negative regulation of osteoblast differentiation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048168	biological_process	regulation of neuronal synaptic plasticity
A	0048318	biological_process	axial mesoderm development
A	0048570	biological_process	notochord morphogenesis
A	0048646	biological_process	anatomical structure formation involved in morphogenesis
A	0048706	biological_process	embryonic skeletal system development
A	0048712	biological_process	negative regulation of astrocyte differentiation
A	0048762	biological_process	mesenchymal cell differentiation
A	0048863	biological_process	stem cell differentiation
A	0050673	biological_process	epithelial cell proliferation
A	0050679	biological_process	positive regulation of epithelial cell proliferation
A	0051216	biological_process	cartilage development
A	0055009	biological_process	atrial cardiac muscle tissue morphogenesis
A	0060044	biological_process	negative regulation of cardiac muscle cell proliferation
A	0060173	biological_process	limb development
A	0060272	biological_process	embryonic skeletal joint morphogenesis
A	0060291	biological_process	long-term synaptic potentiation
A	0060302	biological_process	negative regulation of cytokine activity
A	0060325	biological_process	face morphogenesis
A	0060392	biological_process	negative regulation of SMAD protein signal transduction
A	0060412	biological_process	ventricular septum morphogenesis
A	0060425	biological_process	lung morphogenesis
A	0060513	biological_process	prostatic bud formation
A	0060676	biological_process	ureteric bud formation
A	0061037	biological_process	negative regulation of cartilage development
A	0061053	biological_process	somite development
A	0061384	biological_process	heart trabecula morphogenesis
A	0061626	biological_process	pharyngeal arch artery morphogenesis
A	0062044	biological_process	negative regulation of cardiac epithelial to mesenchymal transition
A	0071773	biological_process	cellular response to BMP stimulus
A	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
A	0090190	biological_process	positive regulation of branching involved in ureteric bud morphogenesis
A	0090193	biological_process	positive regulation of glomerulus development
A	0098793	cellular_component	presynapse
A	0099171	biological_process	presynaptic modulation of chemical synaptic transmission
A	1904888	biological_process	cranial skeletal system development
A	1990926	biological_process	short-term synaptic potentiation
A	2001234	biological_process	negative regulation of apoptotic signaling pathway
L	0005576	cellular_component	extracellular region
L	0008083	molecular_function	growth factor activity

Functional Information from PROSITE/UniProt

site_id	PS00250
Number of Residues	16
Details	TGF_BETA_1 TGF-beta family signature. IiaPegYaayyCeGeC

Chain	Residue	Details
L	ILE56-CYS71

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN62
L	ASN29

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12478285, ECO:0000269|PubMed:12667445

Chain	Residue	Details
L	ASN80

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