7SII

Human STING bound to both cGAMP and 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide (Compound 53)

Summary for 7SII

• Entry DOI: 10.2210/pdb7sii/pdb
• EMDB information: 25142
• Descriptor: Stimulator of interferon genes protein, 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, cGAMP (3 entities in total)
• Functional Keywords: sting, agonist, activate conformation, oligomer, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 160544.17

Authors

Lu, D.,Shang, G.,Jie, L.,Lu, Y.,Bai, X.C.,Zhang, X. (deposition date: 2021-10-14, release date: 2022-02-02, Last modification date: 2022-05-04)

• Primary citation: Lu, D.,Shang, G.,Li, J.,Lu, Y.,Bai, X.C.,Zhang, X.; Activation of STING by targeting a pocket in the transmembrane domain.; Nature, 604:557-562, 2022; PubMed: 35388221; DOI: 10.1038/s41586-022-04559-7

Experimental method

ELECTRON MICROSCOPY (3.45 Å)