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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7SII

Human STING bound to both cGAMP and 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide (Compound 53)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000139cellular_componentGolgi membrane
A0000166molecular_functionnucleotide binding
A0000421cellular_componentautophagosome membrane
A0002218biological_processactivation of innate immune response
A0002221biological_processpattern recognition receptor signaling pathway
A0002230biological_processpositive regulation of defense response to virus by host
A0002376biological_processimmune system process
A0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
A0003713molecular_functiontranscription coactivator activity
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005741cellular_componentmitochondrial outer membrane
A0005768cellular_componentendosome
A0005776cellular_componentautophagosome
A0005777cellular_componentperoxisome
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005929cellular_componentcilium
A0006811biological_processmonoatomic ion transport
A0006914biological_processautophagy
A0010468biological_processregulation of gene expression
A0015252molecular_functionproton channel activity
A0016239biological_processpositive regulation of macroautophagy
A0019901molecular_functionprotein kinase binding
A0030659cellular_componentcytoplasmic vesicle membrane
A0030667cellular_componentsecretory granule membrane
A0031410cellular_componentcytoplasmic vesicle
A0031625molecular_functionubiquitin protein ligase binding
A0032481biological_processpositive regulation of type I interferon production
A0032728biological_processpositive regulation of interferon-beta production
A0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0035438molecular_functioncyclic-di-GMP binding
A0035458biological_processcellular response to interferon-beta
A0035591molecular_functionsignaling adaptor activity
A0036064cellular_componentciliary basal body
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0045087biological_processinnate immune response
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048471cellular_componentperinuclear region of cytoplasm
A0050727biological_processregulation of inflammatory response
A0051259biological_processprotein complex oligomerization
A0051607biological_processdefense response to virus
A0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
A0061507molecular_function2',3'-cyclic GMP-AMP binding
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0061709biological_processreticulophagy
A0070972biological_processprotein localization to endoplasmic reticulum
A0071360biological_processcellular response to exogenous dsRNA
A0120283molecular_functionprotein serine/threonine kinase binding
A0140374biological_processantiviral innate immune response
A0140896biological_processcGAS/STING signaling pathway
A1902554cellular_componentserine/threonine protein kinase complex
A1902600biological_processproton transmembrane transport
A1990231cellular_componentSTING complex
B0000045biological_processautophagosome assembly
B0000139cellular_componentGolgi membrane
B0000166molecular_functionnucleotide binding
B0000421cellular_componentautophagosome membrane
B0002218biological_processactivation of innate immune response
B0002221biological_processpattern recognition receptor signaling pathway
B0002230biological_processpositive regulation of defense response to virus by host
B0002376biological_processimmune system process
B0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
B0003713molecular_functiontranscription coactivator activity
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005741cellular_componentmitochondrial outer membrane
B0005768cellular_componentendosome
B0005776cellular_componentautophagosome
B0005777cellular_componentperoxisome
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005929cellular_componentcilium
B0006811biological_processmonoatomic ion transport
B0006914biological_processautophagy
B0010468biological_processregulation of gene expression
B0015252molecular_functionproton channel activity
B0016239biological_processpositive regulation of macroautophagy
B0019901molecular_functionprotein kinase binding
B0030659cellular_componentcytoplasmic vesicle membrane
B0030667cellular_componentsecretory granule membrane
B0031410cellular_componentcytoplasmic vesicle
B0031625molecular_functionubiquitin protein ligase binding
B0032481biological_processpositive regulation of type I interferon production
B0032728biological_processpositive regulation of interferon-beta production
B0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0035438molecular_functioncyclic-di-GMP binding
B0035458biological_processcellular response to interferon-beta
B0035591molecular_functionsignaling adaptor activity
B0036064cellular_componentciliary basal body
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0045087biological_processinnate immune response
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048471cellular_componentperinuclear region of cytoplasm
B0050727biological_processregulation of inflammatory response
B0051259biological_processprotein complex oligomerization
B0051607biological_processdefense response to virus
B0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
B0061507molecular_function2',3'-cyclic GMP-AMP binding
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0061709biological_processreticulophagy
B0070972biological_processprotein localization to endoplasmic reticulum
B0071360biological_processcellular response to exogenous dsRNA
B0120283molecular_functionprotein serine/threonine kinase binding
B0140374biological_processantiviral innate immune response
B0140896biological_processcGAS/STING signaling pathway
B1902554cellular_componentserine/threonine protein kinase complex
B1902600biological_processproton transmembrane transport
B1990231cellular_componentSTING complex
C0000045biological_processautophagosome assembly
C0000139cellular_componentGolgi membrane
C0000166molecular_functionnucleotide binding
C0000421cellular_componentautophagosome membrane
C0002218biological_processactivation of innate immune response
C0002221biological_processpattern recognition receptor signaling pathway
C0002230biological_processpositive regulation of defense response to virus by host
C0002376biological_processimmune system process
C0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
C0003713molecular_functiontranscription coactivator activity
C0005515molecular_functionprotein binding
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005741cellular_componentmitochondrial outer membrane
C0005768cellular_componentendosome
C0005776cellular_componentautophagosome
C0005777cellular_componentperoxisome
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005929cellular_componentcilium
C0006811biological_processmonoatomic ion transport
C0006914biological_processautophagy
C0010468biological_processregulation of gene expression
C0015252molecular_functionproton channel activity
C0016239biological_processpositive regulation of macroautophagy
C0019901molecular_functionprotein kinase binding
C0030659cellular_componentcytoplasmic vesicle membrane
C0030667cellular_componentsecretory granule membrane
C0031410cellular_componentcytoplasmic vesicle
C0031625molecular_functionubiquitin protein ligase binding
C0032481biological_processpositive regulation of type I interferon production
C0032728biological_processpositive regulation of interferon-beta production
C0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0035438molecular_functioncyclic-di-GMP binding
C0035458biological_processcellular response to interferon-beta
C0035591molecular_functionsignaling adaptor activity
C0036064cellular_componentciliary basal body
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0045087biological_processinnate immune response
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0048471cellular_componentperinuclear region of cytoplasm
C0050727biological_processregulation of inflammatory response
C0051259biological_processprotein complex oligomerization
C0051607biological_processdefense response to virus
C0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
C0061507molecular_function2',3'-cyclic GMP-AMP binding
C0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
C0061709biological_processreticulophagy
C0070972biological_processprotein localization to endoplasmic reticulum
C0071360biological_processcellular response to exogenous dsRNA
C0120283molecular_functionprotein serine/threonine kinase binding
C0140374biological_processantiviral innate immune response
C0140896biological_processcGAS/STING signaling pathway
C1902554cellular_componentserine/threonine protein kinase complex
C1902600biological_processproton transmembrane transport
C1990231cellular_componentSTING complex
D0000045biological_processautophagosome assembly
D0000139cellular_componentGolgi membrane
D0000166molecular_functionnucleotide binding
D0000421cellular_componentautophagosome membrane
D0002218biological_processactivation of innate immune response
D0002221biological_processpattern recognition receptor signaling pathway
D0002230biological_processpositive regulation of defense response to virus by host
D0002376biological_processimmune system process
D0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
D0003713molecular_functiontranscription coactivator activity
D0005515molecular_functionprotein binding
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005741cellular_componentmitochondrial outer membrane
D0005768cellular_componentendosome
D0005776cellular_componentautophagosome
D0005777cellular_componentperoxisome
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005929cellular_componentcilium
D0006811biological_processmonoatomic ion transport
D0006914biological_processautophagy
D0010468biological_processregulation of gene expression
D0015252molecular_functionproton channel activity
D0016239biological_processpositive regulation of macroautophagy
D0019901molecular_functionprotein kinase binding
D0030659cellular_componentcytoplasmic vesicle membrane
D0030667cellular_componentsecretory granule membrane
D0031410cellular_componentcytoplasmic vesicle
D0031625molecular_functionubiquitin protein ligase binding
D0032481biological_processpositive regulation of type I interferon production
D0032728biological_processpositive regulation of interferon-beta production
D0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0035438molecular_functioncyclic-di-GMP binding
D0035458biological_processcellular response to interferon-beta
D0035591molecular_functionsignaling adaptor activity
D0036064cellular_componentciliary basal body
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0045087biological_processinnate immune response
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0048471cellular_componentperinuclear region of cytoplasm
D0050727biological_processregulation of inflammatory response
D0051259biological_processprotein complex oligomerization
D0051607biological_processdefense response to virus
D0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
D0061507molecular_function2',3'-cyclic GMP-AMP binding
D0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
D0061709biological_processreticulophagy
D0070972biological_processprotein localization to endoplasmic reticulum
D0071360biological_processcellular response to exogenous dsRNA
D0120283molecular_functionprotein serine/threonine kinase binding
D0140374biological_processantiviral innate immune response
D0140896biological_processcGAS/STING signaling pathway
D1902554cellular_componentserine/threonine protein kinase complex
D1902600biological_processproton transmembrane transport
D1990231cellular_componentSTING complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues64
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues54
DetailsTopological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues84
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues56
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues68
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"30842659","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22579474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22705373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728659","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F9G","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728659","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"37379839","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8GJX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22579474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22705373","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728658","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22728660","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EF4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F9G","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"37832545","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"37832545","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"Q3TBT3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"29973723","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues12
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"31968013","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"19285439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21074459","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243911

PDB entries from 2025-10-29

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