PDB: 433 件ウェブページステータス検索Chemie searchBIRD

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7YW1	crystal structure of UBE2O 分子名称: (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O 著者 Fu, Z, Zhu, W, Huang, H. 登録日 2022-08-20 公開日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.27 Å) 主引用文献 crystal structure of UBE2O To Be Published
3SY2	Crystal structure of the Salmonella E3 ubiquitin ligase SopA in complex with the human E2 UbcH7 分子名称: E3 ubiquitin-protein ligase SopA, SULFATE ION, Ubiquitin-conjugating enzyme E2 L3 著者 Diao, J, Lin, D.Y, Chen, J. 登録日 2011-07-15 公開日 2012-01-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.27 Å) 主引用文献 Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions. Proc.Natl.Acad.Sci.USA, 109, 2012
7LYB	Cryo-EM structure of the human nucleosome core particle in complex with BRCA1-BARD1-UbcH5c 分子名称: BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ... 著者 Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G. 登録日 2021-03-06 公開日 2021-07-28 最終更新日 2021-09-01 実験手法 ELECTRON MICROSCOPY (3.28 Å) 主引用文献 Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation. Nature, 596, 2021
4R8P	Crystal structure of the Ring1B/Bmi1/UbcH5c PRC1 ubiquitylation module bound to the nucleosome core particle 分子名称: DNA (147-mer), E3 ubiquitin-protein ligase RING2, Ubiquitin-conjugating enzyme E2 D3, ... 著者 McGinty, R.K, Henrici, R.C, Tan, S. 登録日 2014-09-02 公開日 2014-11-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.2846 Å) 主引用文献 Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome. Nature, 514, 2014
4DDG	Crystal structure of human OTUB1/UbcH5b~Ub/Ub 分子名称: Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 D2, Ubiquitin thioesterase OTUB1 著者 Juang, Y.C, Sanches, M, Sicheri, F. 登録日 2012-01-18 公開日 2012-02-22 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.2987 Å) 主引用文献 OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function. Mol.Cell, 45, 2012
9B5L	Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - Ub(T) class 10 map and model from cluster 5 (Ub(A)-AMP) 分子名称: 4-aminobutanenitrile, ADENOSINE MONOPHOSPHATE, Polyubiquitin, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 最終更新日 2024-09-18 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024
8SMW	Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 1) 分子名称: DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... 著者 Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. 登録日 2023-04-26 公開日 2024-01-17 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
8SN1	Cryo-EM structure of the human nucleosome core particle in complex with RNF168 and UbcH5c~Ub (UbcH5c chemically conjugated to histone H2A. No density for Ub.) (class 6) 分子名称: DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... 著者 Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. 登録日 2023-04-26 公開日 2024-01-17 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
8ATU	Cryo-EM structure of human BIRC6 分子名称: Baculoviral IAP repeat-containing protein 6, ZINC ION 著者 Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. 登録日 2022-08-24 公開日 2023-02-15 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex. Science, 379, 2023
3JVZ	E2~Ubiquitin-HECT 分子名称: E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2 著者 Souphron, J, Kamadurai, H.B, Schulman, B.A. 登録日 2009-09-17 公開日 2010-01-12 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex. Mol.Cell, 36, 2009
7UN6	Complex of UBE2O with NAP1L1 分子名称: (E3-independent) E2 ubiquitin-conjugating enzyme, Nucleosome assembly protein 1-like 1 著者 Yip, M.C.J, Sedor, S.F, Shao, S. 登録日 2022-04-09 公開日 2022-08-03 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Mechanism of client selection by the protein quality-control factor UBE2O. Nat.Struct.Mol.Biol., 29, 2022
3SQV	Crystal Structure of E. coli O157:H7 E3 ubiquitin ligase, NleL, with a human E2, UbcH7 分子名称: GLYCEROL, SULFATE ION, Ubiquitin-conjugating enzyme E2 L3, ... 著者 Lin, D.Y, Chen, J. 登録日 2011-07-06 公開日 2012-01-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions. Proc.Natl.Acad.Sci.USA, 109, 2012
8ATM	Structure of the giant inhibitor of apoptosis, BIRC6 (composite map) 分子名称: Baculoviral IAP repeat-containing protein 6 著者 Dietz, L, Elliott, P.R. 登録日 2022-08-23 公開日 2023-03-08 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6. Science, 379, 2023
9B5B	Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 7 分子名称: 4-aminobutanenitrile, E3 ubiquitin-protein ligase pub2, Ubiquitin, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 最終更新日 2024-09-18 実験手法 ELECTRON MICROSCOPY (3.31 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024
7P47	Structure of the E3 ligase Smc5/Nse2 in complex with Ubc9-SUMO thioester mimetic 分子名称: E3 SUMO-protein ligase MMS21, SUMO-conjugating enzyme UBC9, Structural maintenance of chromosomes protein 5, ... 著者 Lascorz, J, Varejao, N, Reverter, D. 登録日 2021-07-09 公開日 2021-11-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.314 Å) 主引用文献 Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs. Nat Commun, 12, 2021
9B56	Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 2 分子名称: 4-aminobutanenitrile, E3 ubiquitin-protein ligase pub2, Ubiquitin, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 最終更新日 2024-09-18 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024
7MEX	Structure of yeast Ubr1 in complex with Ubc2 and N-degron 分子名称: E3 ubiquitin-protein ligase UBR1, N-degron, Ubiquitin, ... 著者 Pan, M, Zheng, Q, Wang, T, Liang, L, Yu, Y, Liu, L, Zhao, M. 登録日 2021-04-08 公開日 2021-11-24 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature, 600, 2021
9B57	Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 3 分子名称: 4-aminobutanenitrile, E3 ubiquitin-protein ligase pub2, Ubiquitin, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 最終更新日 2024-09-18 実験手法 ELECTRON MICROSCOPY (3.37 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024
8SV8	Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex from a composite map 分子名称: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... 著者 Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. 登録日 2023-05-15 公開日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.38 Å) 主引用文献 Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun, 14, 2023
9B58	Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 4 分子名称: 4-aminobutanenitrile, E3 ubiquitin-protein ligase pub2, Ubiquitin, ... 著者 Kochanczyk, T, Lima, C.D. 登録日 2024-03-22 公開日 2024-06-05 最終更新日 2024-09-18 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024
8X7J	Cryo-EM structures of RNF168/UbcH5c-Ub/nucleosomes complex determined by activity-based chemical trapping strategy 分子名称: DNA (144-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... 著者 Ai, H.S, Tong, Z.B, Deng, Z.H, Pan, M, Liu, L. 登録日 2023-11-24 公開日 2024-08-07 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168 Biorxiv, 2024
8PJN	Catalytic module of human CTLH E3 ligase bound to multiphosphorylated UBE2H~ubiquitin 分子名称: E3 ubiquitin-protein transferase MAEA, E3 ubiquitin-protein transferase RMND5A, Ubiquitin, ... 著者 Chrustowicz, J, Sherpa, D, Prabu, R.J, Schulman, B.A. 登録日 2023-06-23 公開日 2024-01-03 最終更新日 2024-01-31 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies. Mol.Cell, 84, 2024
3OJ4	Crystal structure of the A20 ZnF4, ubiquitin and UbcH5A complex 分子名称: Tumor necrosis factor alpha-induced protein 3, Ubiquitin, Ubiquitin-conjugating enzyme E2 D1, ... 著者 Bosanac, I, Hymowitz, S.G. 登録日 2010-08-20 公開日 2010-12-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling Mol.Cell, 40, 2010
8SEA	Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 1) 分子名称: ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... 著者 Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. 登録日 2023-04-08 公開日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun, 14, 2023
3EB6	Structure of the cIAP2 RING domain bound to UbcH5b 分子名称: Baculoviral IAP repeat-containing protein 3, Ubiquitin-conjugating enzyme E2 D2, ZINC ION 著者 Mace, P.D, Linke, K, Schumacher, F.-R, Smith, C.A, Day, C.L. 登録日 2008-08-27 公開日 2008-09-09 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment. J.Biol.Chem., 283, 2008

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