8PJN

Catalytic module of human CTLH E3 ligase bound to multiphosphorylated UBE2H~ubiquitin

Summary for 8PJN

Entry DOI	10.2210/pdb8pjn/pdb
Related	8PMQ
EMDB information	17705 17706 17707 17709 17710 17713 17715 17716 17717 17764
Descriptor	E3 ubiquitin-protein transferase RMND5A, Ubiquitin-conjugating enzyme E2 H, E3 ubiquitin-protein transferase MAEA, ... (5 entities in total)
Functional Keywords	e3 ubiquitin ligase, e2 ubiquitin-conjugating enzyme, phosphorylation, ctlh, gid, ube2h, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	119368.42
Authors	Chrustowicz, J.,Sherpa, D.,Prabu, R.J.,Schulman, B.A. (deposition date: 2023-06-23, release date: 2024-01-03, Last modification date: 2024-01-31)
Primary citation	Chrustowicz, J.,Sherpa, D.,Li, J.,Langlois, C.R.,Papadopoulou, E.C.,Vu, D.T.,Hehl, L.A.,Karayel, O.,Beier, V.,von Gronau, S.,Muller, J.,Prabu, J.R.,Mann, M.,Kleiger, G.,Alpi, A.F.,Schulman, B.A. Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies. Mol.Cell, 84:293-, 2024 Cited by PubMed: 38113892 DOI: 10.1016/j.molcel.2023.11.027 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation