8PJN
Catalytic module of human CTLH E3 ligase bound to multiphosphorylated UBE2H~ubiquitin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | b | E3 ubiquitin-protein transferase RMND5A | polymer | 391 | 44043.4 | 1 | UniProt (Q9H871) Pfam (PF10607) Pfam (PF13445) In PDB | Homo sapiens (human) | P44CTLH,Protein RMD5 homolog A |
| 2 | 2 | Ubiquitin-conjugating enzyme E2 H | polymer | 183 | 21261.0 | 1 | UniProt (P62256) Pfam (PF00179) In PDB | Homo sapiens (human) | (E3-independent) E2 ubiquitin-conjugating enzyme H,E2 ubiquitin-conjugating enzyme H,UbcH2,Ubiquitin carrier protein H,Ubiquitin-conjugating enzyme E2-20K,Ubiquitin-protein ligase H |
| 3 | i | E3 ubiquitin-protein transferase MAEA | polymer | 396 | 45356.3 | 1 | UniProt (Q7L5Y9) Pfam (PF10607) In PDB | Homo sapiens (human) | Cell proliferation-inducing gene 5 protein,Erythroblast macrophage protein,Human lung cancer oncogene 10 protein,HLC-10,Macrophage erythroblast attacher,P44EMLP |
| 4 | u | Ubiquitin | polymer | 76 | 8576.8 | 1 | UniProt (P0CG48) Pfam (PF00240) In PDB | Homo sapiens (human) | Polyubiquitin-C |
| 5 | b, i | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
2: 1 - 183 (UniProt: P62256)
| PDB | External Database | Details |
|---|---|---|
| Lys 87 | Cys 87 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 119237.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.8 | |
| All* | Total formula weight | 119368.4 |
