8PJN

Catalytic module of human CTLH E3 ligase bound to multiphosphorylated UBE2H~ubiquitin

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0000166	molecular_function	nucleotide binding
2	0000209	biological_process	protein polyubiquitination
2	0004842	molecular_function	ubiquitin-protein transferase activity
2	0005515	molecular_function	protein binding
2	0005524	molecular_function	ATP binding
2	0005634	cellular_component	nucleus
2	0005829	cellular_component	cytosol
2	0006511	biological_process	ubiquitin-dependent protein catabolic process
2	0016567	biological_process	protein ubiquitination
2	0016740	molecular_function	transferase activity
2	0061631	molecular_function	ubiquitin conjugating enzyme activity
2	0070936	biological_process	protein K48-linked ubiquitination
2	0070979	biological_process	protein K11-linked ubiquitination
b	0000151	cellular_component	ubiquitin ligase complex
b	0000209	biological_process	protein polyubiquitination
b	0004842	molecular_function	ubiquitin-protein transferase activity
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0008270	molecular_function	zinc ion binding
b	0016740	molecular_function	transferase activity
b	0034657	cellular_component	GID complex
b	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
b	0046872	molecular_function	metal ion binding
b	0061630	molecular_function	ubiquitin protein ligase activity
i	0000151	cellular_component	ubiquitin ligase complex
i	0003779	molecular_function	actin binding
i	0004842	molecular_function	ubiquitin-protein transferase activity
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005737	cellular_component	cytoplasm
i	0005819	cellular_component	spindle
i	0005826	cellular_component	actomyosin contractile ring
i	0005829	cellular_component	cytosol
i	0005856	cellular_component	cytoskeleton
i	0005886	cellular_component	plasma membrane
i	0007155	biological_process	cell adhesion
i	0007346	biological_process	regulation of mitotic cell cycle
i	0008270	molecular_function	zinc ion binding
i	0015629	cellular_component	actin cytoskeleton
i	0016363	cellular_component	nuclear matrix
i	0016740	molecular_function	transferase activity
i	0033033	biological_process	negative regulation of myeloid cell apoptotic process
i	0034657	cellular_component	GID complex
i	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
i	0043249	biological_process	erythrocyte maturation
i	0046872	molecular_function	metal ion binding
i	0051301	biological_process	cell division
i	0061630	molecular_function	ubiquitin protein ligase activity

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
u	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	Domain: {"description":"LisH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00126","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	108
Details	Zinc finger: {"description":"RING-Gid-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01215","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62257","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	57
Details	Domain: {"description":"CTLH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00058","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Essential for ubiquitin ligase activity","evidences":[{"source":"UniProtKB","id":"P40492","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	75
Details	Domain: {"description":"Ubiquitin-like 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---