Crystal structure of human OTUB1/UbcH5b~Ub/Ub

Summary for 4DDG

DescriptorUbiquitin-conjugating enzyme E2 D2, Ubiquitin thioesterase OTUB1, Polyubiquitin-C (2 entities in total)
Functional Keywordsinhibition, hydrolase-ligase complex, hydrolase/ligase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm  Q96FW1
Ubiquitin: Cytoplasm  P0CG48
Total number of polymer chains18
Total molecular weight377617.23
Juang, Y.C.,Sanches, M.,Sicheri, F. (deposition date: 2012-01-18, release date: 2012-02-22, Last modification date: 2017-11-15)
Primary citation
Juang, Y.C.,Landry, M.C.,Sanches, M.,Vittal, V.,Leung, C.C.,Ceccarelli, D.F.,Mateo, A.R.,Pruneda, J.N.,Mao, D.Y.,Szilard, R.K.,Orlicky, S.,Munro, M.,Brzovic, P.S.,Klevit, R.E.,Sicheri, F.,Durocher, D.
OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function.
Mol.Cell, 45:384-397, 2012
PubMed: 22325355 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2012.01.011
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.28360.1%9.8%4.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report