PDB: 672 件ウェブページステータス検索Chemie searchBIRD

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4N07	Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-344 at 1.87 A resolution 分子名称: 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, CACODYLATE ION, ... 著者 Noerholm, A.B, Frydenvang, K, Kastrup, J.S. 登録日 2013-10-01 公開日 2013-11-20 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold. J.Med.Chem., 56, 2013
4NF4	Crystal structure of GluN1/GluN2A ligand-binding domain in complex with DCKA and glutamate 分子名称: 4-hydroxy-5,7-dimethylquinoline-2-carboxylic acid, GLUTAMIC ACID, Glutamate receptor ionotropic, ... 著者 Annie, J, Tajima, N, Furukawa, H. 登録日 2013-10-30 公開日 2014-03-12 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
4NF5	Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and D-AP5 分子名称: 5-phosphono-D-norvaline, GLYCEROL, GLYCINE, ... 著者 Jespersen, A, Tajima, N, Furukawa, H. 登録日 2013-10-30 公開日 2014-03-12 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (1.903 Å) 主引用文献 Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
4NWD	Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist (2S,4R)-4-(3-Methylamino-3-oxopropyl)glutamic acid at 2.6 A resolution 分子名称: (4R)-4-[3-(methylamino)-3-oxopropyl]-L-glutamic acid, CHLORIDE ION, Glutamate receptor ionotropic, ... 著者 Venskutonyte, R, Larsen, A.P, Frydenvang, K, Gajhede, M, Kastrup, J.S. 登録日 2013-12-06 公開日 2014-08-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Molecular Recognition of Two 2,4-syn-Functionalized (S)-Glutamate Analogues by the Kainate Receptor GluK3 Ligand Binding Domain. Chemmedchem, 9, 2014
4NWC	Crystal structure of the GluK3 ligand-binding domain (S1S2) in complex with the agonist (2S,4R)-4-(3-Methoxy-3-oxopropyl)glutamic acid at 2.01 A resolution. 分子名称: (2S,4R)-4-(3-Methoxy-3-oxopropyl) glutamic acid, CHLORIDE ION, Glutamate receptor ionotropic, ... 著者 Larsen, A.P, Venskutonyte, R, Frydenvang, K, Gajhede, M, Kastrup, J.S. 登録日 2013-12-06 公開日 2014-08-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.012 Å) 主引用文献 Molecular Recognition of Two 2,4-syn-Functionalized (S)-Glutamate Analogues by the Kainate Receptor GluK3 Ligand Binding Domain. Chemmedchem, 9, 2014
4DLD	Crystal structure of the GluK1 ligand-binding domain (S1S2) in complex with the antagonist (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid at 2.0 A resolution 分子名称: (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid, CHLORIDE ION, GLYCEROL, ... 著者 Venskutonyte, R, Frydenvang, K, Kastrup, J.S. 登録日 2012-02-06 公開日 2012-10-10 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors Chemmedchem, 7, 2012
4BDL	Crystal structure of the GluK2 K531A LBD dimer in complex with glutamate 分子名称: GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2, GLUTAMIC ACID, ... 著者 Nayeem, N, Mayans, O, Green, T. 登録日 2012-10-05 公開日 2013-04-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements. Open Biol., 3, 2013
4BDO	Crystal structure of the GluK2 K531A-T779G LBD dimer in complex with kainate 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2, ... 著者 Nayeem, N, Mayans, O, Green, T. 登録日 2012-10-05 公開日 2013-04-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements. Open Biol., 3, 2013
4BDM	Crystal structure of the GluK2 K531A LBD dimer in complex with kainate 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2 著者 Nayeem, N, Mayans, O, Green, T. 登録日 2012-10-05 公開日 2013-04-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements. Open Biol., 3, 2013
4BDN	Crystal structure of the GluK2 K531A-T779G LBD dimer in complex with glutamate 分子名称: GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2, GLUTAMIC ACID, ... 著者 Nayeem, N, Mayans, O, Green, T. 登録日 2012-10-05 公開日 2013-04-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements. Open Biol., 3, 2013
4BDR	Crystal structure of the GluK2 R775A LBD dimer in complex with kainate 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... 著者 Nayeem, N, Mayans, O, Green, T. 登録日 2012-10-05 公開日 2013-04-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements. Open Biol., 3, 2013
3BFT	Structure of the ligand-binding core of GluR2 in complex with the agonist (S)-TDPA at 2.25 A resolution 分子名称: (2S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid, CACODYLATE ION, CHLORIDE ION, ... 著者 Beich-Frandsen, M, Mirza, O, Vestergaard, B, Gajhede, M, Kastrup, J.S. 登録日 2007-11-23 公開日 2008-10-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency. J.Med.Chem., 51, 2008
3B6T	Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686A Mutant in Complex with Quisqualate at 2.1 Resolution 分子名称: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Glutamate receptor 2, SULFATE ION 著者 Cho, Y, Lolis, E, Howe, J.R. 登録日 2007-10-29 公開日 2008-02-05 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating. J.Neurosci., 28, 2008
4E0X	Crystal structure of the kainate receptor GluK1 ligand-binding domain in complex with kainate in the absence of glycerol 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, Glutamate receptor, ... 著者 Frydenvang, K, Kastrup, J.S. 登録日 2012-03-05 公開日 2012-04-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Kainate induces various domain closures in AMPA and kainate receptors. Neurochem Int, 61, 2012
3B7D	Crystal structure of the GLUR2 ligand binding core (HS1S2J) in complex with CNQX at 2.5 A resolution 分子名称: 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile, Glutamate receptor 2 著者 Hays, F.A, Center for Structures of Membrane Proteins (CSMP) 登録日 2007-10-30 公開日 2007-11-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists. Science, 318, 2007
3C36	Crystal structure of GluR5 ligand-binding core in complex with ammonium ions at 1.68 Angstrom resolution 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, AMMONIUM ION, CHLORIDE ION, ... 著者 Mayer, M.L. 登録日 2008-01-27 公開日 2008-06-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Molecular basis of kainate receptor modulation by sodium. Neuron, 58, 2008
3BBR	Crystal structure of the iGluR2 ligand binding core (S1S2J-N775S) in complex with a dimeric positive modulator as well as glutamate at 2.25 A resolution 分子名称: CHLORIDE ION, GLUTAMIC ACID, GLYCEROL, ... 著者 Kastrup, J.S, Gajhede, M. 登録日 2007-11-11 公開日 2007-12-04 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites Chem.Biol., 14, 2007
3C34	Crystal structure of GluR5 ligand-binding core in complex with rubidium at 1.82 Angstrom resolution 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... 著者 Mayer, M.L. 登録日 2008-01-27 公開日 2008-06-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Molecular basis of kainate receptor modulation by sodium. Neuron, 58, 2008
3B6Q	Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) Mutant T686A in Complex with Glutamate at 2.0 Resolution 分子名称: GLUTAMIC ACID, Glutamate receptor 2, SULFATE ION 著者 Cho, Y, Lolis, E, Howe, J.R. 登録日 2007-10-29 公開日 2008-02-05 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating. J.Neurosci., 28, 2008
3B6W	Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686S Mutant in Complex with Glutamate at 1.7 Resolution 分子名称: GLUTAMIC ACID, Glutamate receptor 2, SULFATE ION 著者 Cho, Y, Lolis, E, Howe, J.R. 登録日 2007-10-29 公開日 2008-02-05 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating. J.Neurosci., 28, 2008
3BFU	Structure of the ligand-binding core of GluR2 in complex with the agonist (R)-TDPA at 1.95 A resolution 分子名称: (2R)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid, Glutamate receptor 2 著者 Beich-Frandsen, M, Mirza, O, Vestergaard, B, Gajhede, M, Kastrup, J.S. 登録日 2007-11-23 公開日 2008-10-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency. J.Med.Chem., 51, 2008
3C33	Crystal structure of GluR5 ligand-binding core in complex with potassium at 1.78 Angstrom resolution 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... 著者 Mayer, M.L. 登録日 2008-01-27 公開日 2008-06-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Molecular basis of kainate receptor modulation by sodium. Neuron, 58, 2008
4E0W	Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with kainate 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, Glutamate receptor, ... 著者 Venskutonyte, R, Frydenvang, K, Kastrup, J.S. 登録日 2012-03-05 公開日 2012-05-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.3501 Å) 主引用文献 Kainate induces various domain closures in AMPA and kainate receptors. Neurochem Int, 61, 2012
2ZNS	Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GluR5, in complex with glutamate 分子名称: GLUTAMIC ACID, Glutamate receptor, ionotropic kainate 1 著者 Unno, M, Sasaki, M, Ikeda-Saito, M. 登録日 2008-05-01 公開日 2009-05-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011
2ZNU	Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GluR5, in complex with a novel selective agonist, neodysiherbaine A 分子名称: (2R,3aR,6R,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6,7-dihydroxyhexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, BETA-MERCAPTOETHANOL, Glutamate receptor, ... 著者 Unno, M, Sasaki, M, Ikeda-Saito, M. 登録日 2008-05-01 公開日 2009-05-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors. J.Mol.Biol., 413, 2011

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