4NWD

Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist (2S,4R)-4-(3-Methylamino-3-oxopropyl)glutamic acid at 2.6 A resolution

Summary for 4NWD

• Entry DOI: 10.2210/pdb4nwd/pdb
• Related: 3S9E 4MH5 4NWC
• Descriptor: Glutamate receptor ionotropic, kainate 3, (4R)-4-[3-(methylamino)-3-oxopropyl]-L-glutamic acid, POTASSIUM ION, ... (5 entities in total)
• Functional Keywords: kainate receptor, ligand binding domain, agonist, ionotropic glutamate receptor, membrabe protein-agonist complex, membrane protein-agonist complex, membrane protein/agonist
• Biological source: Rattus norvegicus (brown rat,rat,rats); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P42264
• Total number of polymer chains: 1
• Total formula weight: 29438.34

Authors

Venskutonyte, R.,Larsen, A.P.,Frydenvang, K.,Gajhede, M.,Kastrup, J.S. (deposition date: 2013-12-06, release date: 2014-08-06, Last modification date: 2023-09-20)

• Primary citation: Venskutonyte, R.,Larsen, A.P.,Frydenvang, K.,Gajhede, M.,Sagot, E.,Assaf, Z.,Gefflaut, T.,Pickering, D.S.,Bunch, L.,Kastrup, J.S.; Molecular Recognition of Two 2,4-syn-Functionalized (S)-Glutamate Analogues by the Kainate Receptor GluK3 Ligand Binding Domain.; Chemmedchem, 9:2254-2259, 2014; PubMed: 25044437; DOI: 10.1002/cmdc.201402204

Experimental method

X-RAY DIFFRACTION (2.6 Å)