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3BFU

Structure of the ligand-binding core of GluR2 in complex with the agonist (R)-TDPA at 1.95 A resolution

Summary for 3BFU
Entry DOI10.2210/pdb3bfu/pdb
Related1FTM 3BFT
DescriptorGlutamate receptor 2, (2R)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid (3 entities in total)
Functional Keywordsampa receptor, glur2, ligand-binding core, agonist, (r)-tdpa, alternative splicing, cell junction, endoplasmic reticulum, glycoprotein, ion transport, ionic channel, lipoprotein, membrane, palmitate, phosphoprotein, postsynaptic cell membrane, rna editing, synapse, transmembrane, transport, membrane protein
Biological sourceRattus norvegicus (Rat)
More
Cellular locationCell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains4
Total formula weight117643.50
Authors
Beich-Frandsen, M.,Mirza, O.,Vestergaard, B.,Gajhede, M.,Kastrup, J.S. (deposition date: 2007-11-23, release date: 2008-10-14, Last modification date: 2023-11-01)
Primary citationBeich-Frandsen, M.,Pickering, D.S.,Mirza, O.,Johansen, T.N.,Greenwood, J.,Vestergaard, B.,Schousboe, A.,Gajhede, M.,Liljefors, T.,Kastrup, J.S.
Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency.
J.Med.Chem., 51:1459-1463, 2008
Cited by
PubMed: 18269227
DOI: 10.1021/jm701126w
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

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