3BFT

Structure of the ligand-binding core of GluR2 in complex with the agonist (S)-TDPA at 2.25 A resolution

Summary for 3BFT

• Entry DOI: 10.2210/pdb3bft/pdb
• Related: 1FTM 3BFU
• Descriptor: Glutamate receptor 2, (2S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid, ZINC ION, ... (7 entities in total)
• Functional Keywords: ampa receptor, glur2, ligand-binding core, agonist, (s)-tdpa, cell junction, endoplasmic reticulum, glycoprotein, ion transport, ionic channel, lipoprotein, membrane, palmitate, phosphoprotein, postsynaptic cell membrane, rna editing, synapse, transmembrane, transport, membrane protein
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P19491
• Total number of polymer chains: 3
• Total formula weight: 88778.09

Authors

Beich-Frandsen, M.,Mirza, O.,Vestergaard, B.,Gajhede, M.,Kastrup, J.S. (deposition date: 2007-11-23, release date: 2008-10-28, Last modification date: 2023-11-01)

• Primary citation: Beich-Frandsen, M.,Pickering, D.S.,Mirza, O.,Johansen, T.N.,Greenwood, J.,Vestergaard, B.,Schousboe, A.,Gajhede, M.,Liljefors, T.,Kastrup, J.S.; Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency.; J.Med.Chem., 51:1459-1463, 2008; PubMed: 18269227; DOI: 10.1021/jm701126w

Experimental method

X-RAY DIFFRACTION (2.27 Å)